GLPBio

VHL Ligand 14

Catalog No.: GC73330Purity:>99.00%
COASDSData Sheet
VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC50 of 196 nM.

Products are for research use only. Not for human use. We do not sell to patients.

VHL Ligand 14
Cas No.: 2010986-87-3
5 mgIn Stock
$384.00
1
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Description

VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC50 of 196 nM.

VHL Ligand 14 (5-10 μM) supports the stability of PROTAC ER degrader, promotes the ER degradation[1].

References:
[1]. Hu J, et al., Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER). J Med Chem. 2019 Feb 14;62(3):1420-1442.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2010986-87-3
Molecular Formula
C25H34N4O4S
Molecular Weight
486.63
Solubility
DMSO : ≥ 100 mg/mL (205.49 mM)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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