Ligand for E3 Ligase

The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Products Related to Ligand for E3 Ligase(166)

GC11697 Pomalidomide (CC-4047)
CAS: 19171-19-8
Purity: >99.50%
An inhibitor of cereblon
GC13473 Lenalidomide hemihydrate
CAS: 847871-99-2
Purity: >99.50%
TNF-α secretion inhibitor
GC14015 Lenalidomide hydrochloride
CAS: 1243329-97-6
Purity: >98%
An analog of thalidomide
GC14976 Lenalidomide (CC-5013)
CAS: 191732-72-6
Purity: >99.50%
Lenalidomide (CC-5013) is a 4-amino-glutamyl analog of thalidomide, with greater potency and without the sedative and neuropathic side effects associated with thalidomide.
GC17054 Thalidomide
CAS: 50-35-1
Purity: >99.50%
Thalidomide is a non-addictive and non-barbiturate sedative that inhibits cereblon with anti-inflammatory and anti-angiogenic properties.
GC18862 CC-885
CAS: 1010100-07-8
Purity: >99.00%
CC-885 is a modulator of the E3 ligase protein cereblon with antiproliferative effects on human myeloid leukemia cell lines.
GC19195 Iberdomide
CAS: 1323403-33-3
Purity: >98.50%
Iberdomide (CC-220) is a cereblon modulator with an IC50 of 60 nM.
GC19302 Protein degrader 1 hydrochloride
CAS: 1448189-80-7
Purity: >99.50%
(S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. Protein degrader 1 hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
GC19375 VH-298
CAS: 2097381-85-4
Purity: >99.50%
VH-298 is a selective VHL (Von Hippel-Lindau) inhibitor (K d =80-90nM).
GC30029 E3 ligase Ligand 3
CAS: 1061605-21-7
Purity: >96%
E3 ligase Ligand 3 (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein.
GC30164 E3 ligase Ligand 4
CAS: 835616-60-9
Purity: >99.00%
E3 ligase Ligand 4 (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 4 (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
GC32433 Protein degrader 1 TFA
CAS: 1631137-51-3
Purity: >98%
(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. Protein degrader 1 TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
GC32711 E3 ligase Ligand 1
CAS: 1948273-03-7
Purity: >98.50%
E3 ligase Ligand 1 (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 ligase Ligand 1 can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
GC32848 E3 ligase Ligand 2
CAS: 5054-59-1
Purity: >99.50%
E3 ligase Ligand 2 (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 2 (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs.
GC33068 TD-106
CAS: 2250288-69-6
Purity: >99.00%
TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
GC33101 E3 ligase Ligand 1A
CAS: 1948273-02-6
Purity: >98.50%
E3 ligase Ligand 1A (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 ligase Ligand 1A can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
GC34291 E3 ligase Ligand 1 dihydrochloride
Purity: >98%
GC34566 E3 ligase Ligand 9
CAS: 2093388-45-3
Purity: >98%
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC34855 VL285
CAS: 1448188-57-5
Purity: >98.00%
VL285 is a potent VHL ligand with an IC50 of 0.34 μM.
GC35924 E3 ligase Ligand 10
CAS: 1073560-68-5
Purity: >98%
E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC35925 E3 ligase Ligand 11
CAS: 2357114-70-4
Purity: >98%
E3 ligase Ligand 11 is the LCL161 derivative based IAP ligand. E3 ligase Ligand 11 can be connected to the ABL ligand for protein by a linker to form SNIPER.
GC35926 E3 ligase Ligand 12
CAS: 2095244-42-9
Purity: >98.50%
E3 ligase Ligand 12 is the LCL161 derivative based IAP ligand. E3 ligase Ligand 12 can be connected to the ABL ligand for protein by a linker to form SNIPER.
GC35927 E3 ligase Ligand 13
Purity: >98%
E3 ligase Ligand 13 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 13 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC35928 E3 ligase Ligand 14
CAS: 2241489-43-8
Purity: >98%
E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC11697	Pomalidomide (CC-4047)	19171-19-8	>99.50%
GC11697	An inhibitor of cereblon
GC13473	Lenalidomide hemihydrate	847871-99-2	>99.50%
GC13473	TNF-α secretion inhibitor
GC14015	Lenalidomide hydrochloride	1243329-97-6	>98%
GC14015	An analog of thalidomide
GC14976	Lenalidomide (CC-5013)	191732-72-6	>99.50%
GC14976	Lenalidomide (CC-5013) is a 4-amino-glutamyl analog of thalidomide, with greater potency and without the sedative and neuropathic side effects associated with thalidomide.
GC17054	Thalidomide	50-35-1	>99.50%
GC17054	Thalidomide is a non-addictive and non-barbiturate sedative that inhibits cereblon with anti-inflammatory and anti-angiogenic properties.
GC18862	CC-885	1010100-07-8	>99.00%
GC18862	CC-885 is a modulator of the E3 ligase protein cereblon with antiproliferative effects on human myeloid leukemia cell lines.
GC19195	Iberdomide	1323403-33-3	>98.50%
GC19195	Iberdomide (CC-220) is a cereblon modulator with an IC50 of 60 nM.
GC19302	Protein degrader 1 hydrochloride	1448189-80-7	>99.50%
GC19302	(S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. Protein degrader 1 hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
GC19375	VH-298	2097381-85-4	>99.50%
GC19375	VH-298 is a selective VHL (Von Hippel-Lindau) inhibitor (K d =80-90nM).
GC30029	E3 ligase Ligand 3	1061605-21-7	>96%
GC30029	E3 ligase Ligand 3 (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein.
GC30164	E3 ligase Ligand 4	835616-60-9	>99.00%
GC30164	E3 ligase Ligand 4 (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 4 (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
GC32433	Protein degrader 1 TFA	1631137-51-3	>98%
GC32433	(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. Protein degrader 1 TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
GC32711	E3 ligase Ligand 1	1948273-03-7	>98.50%
GC32711	E3 ligase Ligand 1 (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 ligase Ligand 1 can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
GC32848	E3 ligase Ligand 2	5054-59-1	>99.50%
GC32848	E3 ligase Ligand 2 (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 2 (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs.
GC33068	TD-106	2250288-69-6	>99.00%
GC33068	TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
GC33101	E3 ligase Ligand 1A	1948273-02-6	>98.50%
GC33101	E3 ligase Ligand 1A (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 ligase Ligand 1A can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
GC34291	E3 ligase Ligand 1 dihydrochloride	-	>98%
GC34566	E3 ligase Ligand 9	2093388-45-3	>98%
GC34566	E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC34855	VL285	1448188-57-5	>98.00%
GC34855	VL285 is a potent VHL ligand with an IC50 of 0.34 μM.
GC35924	E3 ligase Ligand 10	1073560-68-5	>98%
GC35924	E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC35925	E3 ligase Ligand 11	2357114-70-4	>98%
GC35925	E3 ligase Ligand 11 is the LCL161 derivative based IAP ligand. E3 ligase Ligand 11 can be connected to the ABL ligand for protein by a linker to form SNIPER.
GC35926	E3 ligase Ligand 12	2095244-42-9	>98.50%
GC35926	E3 ligase Ligand 12 is the LCL161 derivative based IAP ligand. E3 ligase Ligand 12 can be connected to the ABL ligand for protein by a linker to form SNIPER.
GC35927	E3 ligase Ligand 13	-	>98%
GC35927	E3 ligase Ligand 13 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 13 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
GC35928	E3 ligase Ligand 14	2241489-43-8	>98%
GC35928	E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.