Zelpolib is a non-competitive Pol δ inhibitor. Zelpolib shows robust inhibition of Pol δ activity against dTTP with a K i of 4.3 μM. Zelpolib inhibits cellular DNA replication. Zelpolib shows antiproliferative properties [1].
References:
[1]. Mishra B, et al. Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties. Cancer Biol Ther. 2019;20(4):474-486.
References:
[1]. Mishra B, et al. Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties. Cancer Biol Ther. 2019;20(4):474-486.
















