2-Tetralone (Beta-Tetralone) is a cyclic bis-sterically hindered ketone and a ketone derivative of tetrafluoramine. 2-Tetralone exhibits anticancer activity, inhibits cell migration and proliferation, and induces apoptosis. 2-Tetralone is often used as a pharmaceutical intermediate in studies related to organic synthesis [1] [2].
In Vitro, 2-Tetralone (Beta-Tetralone) (100-300 μM; 48 h) induces cell death, inhibits cell migration and proliferation, and triggers apoptosis in MCF-7 breast cancer cells [1]. 2-Tetralone serves as a precursor for chlorine-substituted fused ring systems and optically enriched 2-tetralols, and acts as a substrate for asymmetric reduction by the secondary alcohol dehydrogenase (TeSADH) mutant from Thermoanaerobacter pseudoethanolicus to produce (S)-2-tetralol[2].
References:
[1]. Shaikh N. Screening of natural product libraries in MCF7 cell line reveals the pro-apoptotic properties of β tetralone. J Biomol Struct Dyn. 2024 Jan-Feb;42(2):876-884.
[2]. Bsharat O, et al. Asymmetric Reduction of Substituted 2‑Tetralones by Thermoanaerobacter pseudoethanolicus Secondary Alcohol Dehydrogenase. ChemCatChem, 2017, 9(8):1487‑1493.
In Vitro, 2-Tetralone (Beta-Tetralone) (100-300 μM; 48 h) induces cell death, inhibits cell migration and proliferation, and triggers apoptosis in MCF-7 breast cancer cells [1]. 2-Tetralone serves as a precursor for chlorine-substituted fused ring systems and optically enriched 2-tetralols, and acts as a substrate for asymmetric reduction by the secondary alcohol dehydrogenase (TeSADH) mutant from Thermoanaerobacter pseudoethanolicus to produce (S)-2-tetralol[2].
References:
[1]. Shaikh N. Screening of natural product libraries in MCF7 cell line reveals the pro-apoptotic properties of β tetralone. J Biomol Struct Dyn. 2024 Jan-Feb;42(2):876-884.
[2]. Bsharat O, et al. Asymmetric Reduction of Substituted 2‑Tetralones by Thermoanaerobacter pseudoethanolicus Secondary Alcohol Dehydrogenase. ChemCatChem, 2017, 9(8):1487‑1493.