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25-Hydroxycholesterol (Synonyms: 25-OH Cholesterol)

Catalog No.GC33860

An oxysterol

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25-Hydroxycholesterol Chemical Structure

Cas No.: 2140-46-7

Size Price Stock Qty
10mM (in 1mL DMSO)
$39.00
In stock
5mg
$35.00
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10mg
$49.00
In stock
25mg
$98.00
In stock
50mg
$168.00
In stock
100mg
$259.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1].

[1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.

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