4E2RCat |
| Catalog No.GC30785 |
4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 432499-63-3
Sample solution is provided at 25 µL, 10mM.
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4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner[1].
4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1].
[1]. Cencic R, et al. Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9.
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