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Acetyl-CoA Carboxylase

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Acetyl-CoA carboxylase (ACC) is a biotin carboxylase that catalyzes the ATP-dependent condensation of acetyl-CoA and carbonate to form malonyl-CoA. The malonyl-CoA produced by ACC serves two major physiologic functions. It is an essential and rate-limiting substrate for de novo lipogenesis (DNL), and it acts as an allosteric inhibitor of the enzyme carnitine-palmitoyl transferase I (CPT-1). Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer.

Acetyl-CoA carboxylase (ACC) in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks CPT-1 function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Products Related to Acetyl-CoA Carboxylase(21)

  • GC27869 structure
    GC27869hACC2-IN-1
    CAS: 192323-14-1
    Purity: >99.50%

    hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC 50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research.

  • GC27870 structure
    GC27870ACC1/2-IN-2
    CAS: 1031411-94-5
    Purity: >99.00%

    ACC1/2-IN-2 (compound PF-3) is a potent ACC1/2 inhibitor with IC 50 values of 22 and 48 nM for ACC1 and ACC2, respectively.

  • GC13434 structure
    GC13434CP-640186
    CAS: 591778-68-6
    Purity: >98.50%

    isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor

  • GC19261 structure
    GC19261ND-630 (Firsocostat)
    CAS: 1434635-54-7
    Purity: >98.00%

    ND-630 (Firsocostat) is an acetyl-CoA carboxylase (ACC) inhibitor that suppresses the activity of ACC1 (IC 50 =2.1nM) and ACC2 (IC 50 =6.1nM).

  • GC19284 structure
    GC19284PF-05175157
    CAS: 1301214-47-0
    Purity: >98.00%

    PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.

  • GC25726 structure
    GC25726PF-05221304
    CAS: 1370448-25-1
    Purity: >98%

    PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).

  • GC30047 structure
    GC30047Olumacostat glasaretil
    CAS: 1261491-89-7
    Purity: >98.50%

    Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC).

  • GC31344 structure
    GC31344MK-4074
    CAS: 1039758-22-9
    Purity: >99.50%

    MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM.

  • GC32706 structure
    GC32706ND-646
    CAS: 1434639-57-2
    Purity: >98.50%

    ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

  • GC32715 structure
    GC32715TOFA (RMI14514)
    CAS: 54857-86-2
    Purity: >98.00%

    TOFA (RMI14514) is a conformational inhibitor of acetyl-CoA carboxylase-α (ACCA).

  • GC35740 structure
    GC35740CP-640186 hydrochloride
    CAS: 591778-70-0
    Purity: >99.50%

    CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

  • GC61758 structure
    GC61758Fluazifop-P-butyl
    CAS: 79241-46-6
    Purity: >98.50%

    Fluazifop-P-butyl, a graminicide from arylophenoxypropionate group, is a acetyl-CoA carboxylase (ACCase) inhibitor.

  • GC64300 structure
    GC64300Haloxyfop
    CAS: 69806-34-4
    Purity: >98%

    Haloxyfop is an aryloxyphenoxypropionic acid herbicide and is widely used in grass weeds in broad-leaf crops.

  • GC64681 structure
    GC64681VY-3-135
    CAS: 1824637-41-3
    Purity: >99.00%

    VY-3-135 is a potent and orally stable ACSS2 inhibitor with an IC 50 value of 44±3.85nM and a water solubility of 21.7μM.

  • GC68587 structure
    GC68587A-908292
    CAS: 903886-95-3
    Purity: >99.00%

    A-908292 is an effective and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), with an IC50 value of 23 nM for hACC2. A-908292 can be used in the study of fatty acid metabolism.

  • GC68603 structure
    GC68603Acetyl-CoA Carboxylase-IN-1
    CAS: 179343-23-8
    Purity: >99.00%

    Acetyl-CoA Carboxylase-IN-1 is an effective inhibitor of acetyl-coenzyme A carboxylase (ACC), with an IC50 value of

  • GC70436 structure
    GC70436Propaquizafop
    CAS: 111479-05-1
    Purity: >98.00%

    Propaquizafop is a phenoxyisopropionic acid herbicide and an acetyl-coA carboxylase inhibitor.

  • GC79177 structure
    GC79177AMPK activator 18
    CAS: 1364692-88-5
    Purity: >98.00%

    AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform.

  • GC79552 structure
    GC79552XZA-1
    CAS: 1282141-20-1
    Purity: >99.50%

    XZA-1 is a 3-hydroxyacyl-coenzyme A dehydrogenase ( HADH ) activator.

  • GC79553 structure
    GC79553ACC1/2-IN-3
    CAS: 2131091-32-0
    Purity: >98.00%

    ACC1/2-IN-3 (example 66) is an ACC1 and ACC2 inhibitor with an IC 50 value of 1-10 nM for both.

  • GC79726 structure
    GC79726Selovoxolone
    CAS: 1786406-66-3
    Purity: >98.00%

    Selovoxolone (CKBA), a derivative of AKBA is an inhibitor of acetyl-CoA carboxylase 1 ( ACC1 ), with an IC 50 of 5.02 μM.