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Aldehyde Dehydrogenase (ALDH)

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Aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast cancer stem cells (CSCs), in triple negative breast cancer (TNBC) tissues.

Mitochondrial aldehyde dehydrogenase (ALDH2) is a member of the 19-strong human aldehyde dehydrogenase family of NADP+-dependent enzymes.

ALDH2, a mitochondrial enzyme responsible for metabolizing the major lipid peroxidation product, protects against acute ischemia/reperfusion injury and chronic heart failure. Activation of ALDH2, the main enzyme that catalyzes 4-HNE metabolism, is sufficient to protect the heart against acute ischemia-reperfusion injury.

ALDH2 is a key detoxifying enzyme. ALDH2 is most commonly associated with its role in ethanol metabolism, catalyzing the oxidation of ethanol-derived acetaldehyde to acetate.

Products Related to Aldehyde Dehydrogenase (ALDH)(31)

  • GC10016 structure
    GC10016NCT-501
    CAS: 1802088-50-1
    Purity: >99.50%

    Aldehyde Dehydrogenase 1A1 (ALDH1A1) inhibitor, Potent and Selective

  • GC10801 structure
    GC10801Disulfiram
    CAS: 97-77-8
    Purity: >99.50%

    An irreversible inhibitor of aldehyde dehydrogenase

  • GC10902 structure
    GC10902CVT 10216
    CAS: 1005334-57-5
    Purity: >99.00%

    CVT 10216 is a highly selective, reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2), with IC 50 values of 29nM and 1.3μM for ALDH-2 and ALDH-1, respectively.

  • GC16597 structure
    GC16597Alda 1
    CAS: 349438-38-6
    Purity: >99.50%

    Alda 1 is an aldehyde dehydrogenase 2 (ALDH2) activator.

  • GC33219 structure
    GC33219NCT-505
    CAS: 2231079-74-4
    Purity: >98%

    NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM).

  • GC37576 structure
    GC37576RV01
    CAS: 1016897-10-1
    Purity: >98.00%

    RV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity.

  • GC38909 structure
    GC38909EN40
    CAS: 2094547-67-6
    Purity: >98%

    EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM

  • GC39215 structure
    GC39215CM10
    CAS: 692269-09-3
    Purity: >99.50%

    CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively.

  • GC39245 structure
    GC392454-Diethylaminobenzaldehyde
    CAS: 120-21-8
    Purity: >98.00%

    4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM).

  • GC39328 structure
    GC393283-Hydroxybenzaldehyde
    CAS: 100-83-4
    Purity: >98.00%

    3-Hydroxybenzaldehyde?is a precursor compound for phenolic compounds, such as Protocatechualdehyde.

  • GC42410 structure
    GC424104-hydroxy Nonenal
    CAS: 75899-68-2
    Purity: >97.00%

    4-Hydroxy Nonenal (4-HNE) is a product of lipid peroxidation (LPO), an α,β-unsaturated hydroxyalkenal formed from the oxidation of ω-6 polyunsaturated fatty acids, it is a colorless oil.

  • GC43285 structure
    GC43285CM037
    CAS: 896795-60-1
    Purity: >98.00%

    CM037 is a selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1; IC50 = 4.6 μM).

  • GC44338 structure
    GC44338NCT-501 (hydrochloride)
    CAS: 2080306-22-3
    Purity: >98.00%

    Aldehyde dehydrogenases (ALDHs) catalyze the NAD(P)+-dependent oxidation of aldehyde-containing substrates to the corresponding carboxylic acids.

  • GC46002 structure
    GC46002Prunetin
    CAS: 552-59-0
    Purity: >95.00%

    An isoflavone with diverse biological activities

  • GC50613 structure
    GC50613673 A
    CAS: 109437-62-9
    Purity: >98%

    ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)

  • GC60092 structure
    GC60092BODIPY aminoacetaldehyde
    CAS: 247069-94-9
    Purity: >98%

    BODIPY aminoacetaldehyde (BAAA) is a fluorescent substrate for both murine and human aldehyde dehydrogenase (ALDH). BODIPY aminoacetaldehyde consists of an aminoacetaldehyde moiety bonded to the BODIPY fluorochrome and can be used to label stem cells.

  • GC63605 structure
    GC63605Taraxerone
    CAS: 514-07-8
    Purity: >98%

    Taraxerone is isolated from Sedum sarmentosum.

  • GC64063 structure
    GC64063ALDH1A1-IN-2
    CAS: 2231081-18-6
    Purity: >98%

    ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295).

  • GC64618 structure
    GC64618ALDH1A3-IN-3
    CAS: 18962-05-5
    Purity: >99.00%

    ALDH1A3-IN-3 (compound 16) is a potent inhibitor of ALDH1A3, with an IC50 of 0.26 μM. ALDH1A3-IN-3 is also a good ALDH3A1 substrate. ALDH1A3-IN-3 can be used for the research of prostate cancer.

  • GC65274 structure
    GC65274NCT-506
    CAS: 2231098-99-8
    Purity: >99.00%

    NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM.

  • GC67782 structure
    GC67782ALDH1A2-IN-1
    CAS: 2204229-64-9
    Purity: >98.00%
  • GC68009 structure
    GC68009KS106
    CAS: 2408477-50-7
    Purity: >98%
  • GC68462 structure
    GC68462ALDH1A3-IN-2
    CAS: 886502-08-5
    Purity: >98%
  • GC68464 structure
    GC68464ALDH1A3-IN-1
    CAS: 1695970-90-1
    Purity: >98%