GLPBio

Aldose reductase

Aldose reductase catalyzes the NADPH-dependent reduction of glucose to sorbitol. It is involved in the progression of diabetic and glactosemic complications.

Products Related to Aldose reductase(26)

  • GC10001 structure
    GC10001Epalrestat
    CAS: 82159-09-9
    Purity: >99.50%

    Epalrestat is an orally active inhibitor of aldose reductases AKR1B1 and AKR1B10, with IC 50 values of 0.1µM and 0.33µM, respectively.

  • GC10332 structure
    GC10332EBPC
    CAS: 4450-98-0
    Purity: >98%

    aldose reductase inhibitor

  • GC10958 structure
    GC10958Statil
    CAS: 72702-95-5
    Purity: >99.50%

    Statil (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor.

  • GC11756 structure
    GC11756Alrestatin
    CAS: 51411-04-2
    Purity: >99.50%

    aldose reductase inhibitor

  • GC25009 structure
    GC250092-Chloro-1-(4-fluorobenzyl)benzimidazole
    CAS: 84946-20-3
    Purity: >98%

    2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative.

  • GC31359 structure
    GC31359Ranirestat (AS-3201)
    CAS: 147254-64-6
    Purity: >98.00%

    Ranirestat (AS-3201) (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC50s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a Ki of 0.38 nM for recombinant human AR.

  • GC31376 structure
    GC31376Aldose reductase-IN-1
    CAS: 1355612-71-3
    Purity: >99.50%

    Aldose reductase-IN-1 (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC50 of 28.9 pM.

  • GC31412 structure
    GC31412Imirestat (AL 1576)
    CAS: 89391-50-4
    Purity: >99.50%

    Imirestat (AL 1576) (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

  • GC31474 structure
    GC31474Risarestat (CT 112)
    CAS: 79714-31-1
    Purity: >98.00%

    Risarestat (CT 112) (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications.

  • GC31487 structure
    GC31487Fidarestat (SNK 860)
    CAS: 136087-85-9
    Purity: >99.00%

    Fidarestat (SNK 860) (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) (SNK 860) has the potential to treat diabetic disease.

  • GC35179 structure
    GC351796-Methoxytricin
    CAS: 76015-42-4
    Purity: >98%

    6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi.

  • GC35309 structure
    GC35309Alrestatin sodium
    CAS: 51876-97-2
    Purity: >98%

    Alrestatin sodium is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.

  • GC37053 structure
    GC37053Quercetin 3-gentiobioside
    CAS: 7431-83-6
    Purity: >98%

    Quercetin 3-gentiobioside is isolated from A.

  • GC37666 structure
    GC37666Sorbinil
    CAS: 68367-52-2
    Purity: >99.50%

    Sorbinil, is an Aldose reductase inhibitor (ARI).

  • GC37812 structure
    GC37812Tolrestat
    CAS: 82964-04-3
    Purity: >98.50%

    Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.

  • GC38584 structure
    GC38584AT-007
    CAS: 2170729-29-8
    Purity: >99.00%

    AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM.

  • GC38810 structure
    GC38810Lidorestat
    CAS: 245116-90-9
    Purity: >99.50%

    Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM.

  • GC63990 structure
    GC63990Zenarestat
    CAS: 112733-06-9
    Purity: >98%

    Zenarestat is a potent and orally active aldose reductase inhibitor.

  • GC68633 structure
    GC68633AKR1C3-IN-9
    Purity: >99.00%

    AKR1C3-IN-9 is a selective inhibitor of aldo-keto reductase 1C3 (AKR1C3), with an IC50 of 8.92 nM. AKR1C3-IN-9 significantly reverses Doxorubicin (DOX) resistance in drug-resistant breast cancer cell lines.

  • GC68645 structure
    GC68645ALR2-IN-1
    CAS: 2799695-54-6
    Purity: >98%

    ALR2-IN-1 is a potent and selective inhibitor of ALR2 (IC50=1.42 μM). It exhibits antioxidant and antiglycation properties. ALR2-IN-1 can be used for research on complications related to diabetes.

  • GC70493 structure
    GC70493MK204
    CAS: 1959605-73-2

    MK204 is an aldose reductase (AR) inhibitor that can be used in diabetes research.

  • GC70526 structure
    GC70526IDD388
    CAS: 314297-26-2

    IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC50 of 30 nM.

  • GC79559 structure
    GC795592-(2-Chlorobenzamido)acetic acid
    CAS: 16555-60-5
    Purity: >98.00%

    2-(2-Chlorobenzamido)acetic acid is an aldose reductase inhibitor with an IC 50 of 31 μM.

  • GC79560 structure
    GC79560Cemtirestat
    CAS: 309283-89-4
    Purity: >98.00%

    Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase ( ALR2 ).