Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate is now more commonly used due to a more favorable therapeutic index. Aminopterin is a component of the widely used HAT (hypoxanthine-aminopterin-thymidine) medium to select cells for mammalian cell culture.
Aminopterin
Catalog No.: GC42789Purity:>98.00%Synonyms: 4-amino Folic Acid, 4-amino PGA, APGA, NSC 739
Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis.
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Cas No.: 54-62-6
5mgIn Stock
$33.00
1
10mgIn Stock
$59.00
1
25mgIn Stock
$105.00
1
50mgIn Stock
$195.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 5mg | $33.00 | In Stock | 1 | |
| 10mg | $59.00 | In Stock | 1 | |
| 25mg | $105.00 | In Stock | 1 | |
| 50mg | $195.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
54-62-6
Synonyms
4-amino Folic Acid, 4-amino PGA, APGA, NSC 739
SMILES
NC1=NC2=NC=C(CNC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)N=C2C(N)=N1
Molecular Formula
C19H20N8O5
Molecular Weight
440.4
Solubility
DMSO : 14.71 mg/mL (33.40 mM; Need ultrasonic); H2O : 5 mg/mL (11.35 mM; ultrasonic and adjust pH to 8 with NaOH)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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