Ferroptosis
Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.
Products Related to Ferroptosis(211)
- GC17198CycloheximideCAS: 66-81-9Purity: >98.00%
Cycloheximide is an orally active antifungal antibiotic produced by Streptomyces griseus. Cycloheximide inhibits protein synthesis and RNA synthesis in vivo (IC 50 =532.5nM and 2880nM).
- GA10750L-Glutamic acidCAS: 56-86-0Purity: >99.00%
L-Glutamic acid is the main excitatory neurotransmitter in the mammalian central nervous system (CNS). L-Glutamic acid has two major types of receptors: ionotropic (NMDA-, AMPA-, and kainate-selective iGluRs) and metabotropic glutamate receptors. L-Glutamic acid induces excitotoxicity by activating the postsynaptic N-methyl-D-aspartate receptors, leading to neurodegenerative diseases.
- GB10587Gingerenone ACAS: 128700-97-0Purity: >98.00%
Gingerenone A is an orally active Nrf2-Gpx4 activator with an EC 50 value of 24μM.
- GC10132CiclopiroxCAS: 29342-05-0Purity: >99.50%
Ciclopirox (HOE296b) هو عامل مضاد للفطريات يمكن استخدامه لعلاج داء الفطريات السطحية
- GC10282PiperlongumineCAS: 20069-09-4Purity: >98.00%
Piperlongumine is a natural alkaloid compound extracted from Piper longum L. , which has multiple pharmacological activities, including anti-tumor, lipid metabolism regulation, anti-platelet aggregation and analgesic activities.
- GC10345Bay 11-7085CAS: 196309-76-9Purity: >99.00%
BAY 11-7085 (BAY 11-7083) هو مثبط لتنشيط NF-κB وفسفرة IκBα ؛ إنه يستقر IκBα مع IC 50 من 10 ميكرومتر
- GC10585Simvastatin (Zocor)CAS: 79902-63-9Purity: >98.00%
سيمفاستاتين (زوكور) (MK 733) هو مثبط تنافسي لإنزيم HMG-CoA reductase بقيمة Ki تبلغ 0.2 نانومتر.
- GC11120Ciclopirox ethanolamineCAS: 41621-49-2Purity: >99.50%
Ciclopirox ethanolamine (Ciclopirox ethanolamine) هو عامل مضاد للفطريات يمكن استخدامه لعلاج داء الفطريات السطحية.
- GC11572Bardoxolone methylCAS: 218600-53-4Purity: >98.50%
Bardoxolone methyl is an effective activator of the antioxidant and anti-inflammatory response mediated by nuclear factor erythroid 2-related factor 2 (Nrf2), and it is also an inhibitor of the NF-κB pathway.
- GC11633LovastatinCAS: 75330-75-5Purity: >99.50%
Lovastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that impacts the mevalonate pathway, which has an IC 50 value of 77nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC17198 | Cycloheximide | 66-81-9 | >98.00% | |
Cycloheximide is an orally active antifungal antibiotic produced by Streptomyces griseus. Cycloheximide inhibits protein synthesis and RNA synthesis in vivo (IC 50 =532.5nM and 2880nM). | ||||
| GA10750 | L-Glutamic acid | 56-86-0 | >99.00% | |
L-Glutamic acid is the main excitatory neurotransmitter in the mammalian central nervous system (CNS). L-Glutamic acid has two major types of receptors: ionotropic (NMDA-, AMPA-, and kainate-selective iGluRs) and metabotropic glutamate receptors. L-Glutamic acid induces excitotoxicity by activating the postsynaptic N-methyl-D-aspartate receptors, leading to neurodegenerative diseases. | ||||
| GA10942 | H-D-Gln-OH | 5959-95-5 | >99.00% | |
| GA11210 | (H-Cys-OH)2 | 56-89-3 | >99.00% | |
| GA11257 | L-Cysteine | 52-90-4 | >98.00% | |
| GB10587 | Gingerenone A | 128700-97-0 | >98.00% | |
Gingerenone A is an orally active Nrf2-Gpx4 activator with an EC 50 value of 24μM. | ||||
| GC10042 | Vitamin E | 59-02-9 | >98.00% | |
fat-soluble vitamin | ||||
| GC10132 | Ciclopirox | 29342-05-0 | >99.50% | |
Ciclopirox (HOE296b) هو عامل مضاد للفطريات يمكن استخدامه لعلاج داء الفطريات السطحية | ||||
| GC10282 | Piperlongumine | 20069-09-4 | >98.00% | |
Piperlongumine is a natural alkaloid compound extracted from Piper longum L. , which has multiple pharmacological activities, including anti-tumor, lipid metabolism regulation, anti-platelet aggregation and analgesic activities. | ||||
| GC10331 | Ebselen | 60940-34-3 | 99.97% | |
إبسيلين (SPI-1005) ، محاكى الجلوتاثيون بيروكسيديز ، هو مانع قناة الكالسيوم (VDCC) الفعال المعتمد على الجهد | ||||
| GC10345 | Bay 11-7085 | 196309-76-9 | >99.00% | |
BAY 11-7085 (BAY 11-7083) هو مثبط لتنشيط NF-κB وفسفرة IκBα ؛ إنه يستقر IκBα مع IC 50 من 10 ميكرومتر | ||||
| GC10380 | Ferrostatin-1 (Fer-1) | 347174-05-4 | >99.00% | |
مثبط للفيروبتوز. | ||||
| GC10451 | U-73122 | 112648-68-7 | >98.00% | |
مثبط لفوسفوليبيز سي، فوسفوليباز أ2 و 5-LO | ||||
| GC10538 | Pifithrin-α (PFTα) | 63208-82-2 | >98.00% | |
مثبط لبروتين p53 | ||||
| GC10585 | Simvastatin (Zocor) | 79902-63-9 | >98.00% | |
سيمفاستاتين (زوكور) (MK 733) هو مثبط تنافسي لإنزيم HMG-CoA reductase بقيمة Ki تبلغ 0.2 نانومتر. | ||||
| GC10655 | Dexrazoxane | 24584-09-6 | >99.50% | |
Dexrazoxane (ICRF-187) هو عامل واقي للقلب | ||||
| GC10889 | Artesunate | 88495-63-0 | >98.00% | |
مشتق الناتج الطبيعي أرتيمسينين | ||||
| GC10896 | Cyclic Pifithrin-α hydrobromide | 511296-88-1 | >98.00% | |
A stable inhibitor of p53 | ||||
| GC11008 | Necrostatin-1 | 4311-88-0 | >99.00% | |
مثبط لإنزيم RIP1 كيناز | ||||
| GC11120 | Ciclopirox ethanolamine | 41621-49-2 | >99.50% | |
Ciclopirox ethanolamine (Ciclopirox ethanolamine) هو عامل مضاد للفطريات يمكن استخدامه لعلاج داء الفطريات السطحية. | ||||
| GC11152 | Pioglitazone HCl | 112529-15-4 | >99.50% | |
A PPARγ agonist | ||||
| GC11318 | Rosiglitazone maleate | 155141-29-0 | >99.50% | |
A PPARγ agonist | ||||
| GC11572 | Bardoxolone methyl | 218600-53-4 | >98.50% | |
Bardoxolone methyl is an effective activator of the antioxidant and anti-inflammatory response mediated by nuclear factor erythroid 2-related factor 2 (Nrf2), and it is also an inhibitor of the NF-κB pathway. | ||||
| GC11633 | Lovastatin | 75330-75-5 | >99.50% | |
Lovastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that impacts the mevalonate pathway, which has an IC 50 value of 77nM. | ||||