Gambogenic acid |
| رقم الكتالوجGC38062 |
حمض الغامبوجينيك هو عنصر نشط في gamboge ، مع نشاط مضاد للسرطانيعمل حمض الغامبوجينيك كمثبط فعال لـ EZH2 ، ويرتبط بشكل خاص وتساهمي بـ Cys668 ضمن مجال EZH2-SET ، ويحث على انتشار EZH2
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Cas No.: 173932-75-7
Sample solution is provided at 25 µL, 10mM.
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Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination[1].
[1]. Wang X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260.
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