Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases [1] [2] [3] [4] [5].
In Vivo, Isoxanthohumol (20 mg/kg; oral administration; 18 days) exhibits antimetastatic activity in a B16-F10 mouse tumor model[3]. Isoxanthohumol (60 mg/kg; oral gavage; 8 days) shows ameliorative effects in a DSS -induced mouse colitis model[4].
In Vitro, Isoxanthohumol (0-100 μM; 20 min-6 d) reduces the viability, induces apoptosis of mature 3T3-L1 adipocytes, and inhibits the differentiation of 3T3-L1 preadipocytes. The mechanisms are associated with ROS generation and mitochondrial dysfunction[1]. Isoxanthohumol (2.5-50 µg/mL) inhibits Botrytis cinerea, Fusarium graminearum, and Sclerotinia sclerotiorum with EC50 values of 4.32, 16.50, and 14.52 µg/mL, respectively[2]. Isoxanthohumol (1.6-100 μM; 0-7 d) suppresses the proliferation, adhesion, migration, invasion, and colony formation, induces apoptosis and autophagy, and downregulates the integrin signaling pathway in B16-F10 cells[3].
References:
[1]. Yang JY, et al. Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis. Apoptosis. 2007 Nov;12(11):1953-63.
[2]. Yan YF, et al. The Antifungal Mechanism of Isoxanthohumol from Humulus lupulus Linn. Int J Mol Sci. 2021 Oct 7;22(19):10853.
[3]. Krajnović T, et al. The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model. Food Chem Toxicol. 2019 Jul;129:257-268.
[4]. Yang YN, et al. Therapeutic effects and mechanisms of isoxanthohumol on DSS-induced colitis: regulating T cell development, restoring gut microbiota, and improving metabolic disorders. Inflammopharmacology. 2024 Jun;32(3):1983-1998.
[5]. Żołnierczyk AK, et al. Isoxanthohumol--Biologically active hop flavonoid. Fitoterapia. 2015 Jun;103:71-82.
In Vivo, Isoxanthohumol (20 mg/kg; oral administration; 18 days) exhibits antimetastatic activity in a B16-F10 mouse tumor model[3]. Isoxanthohumol (60 mg/kg; oral gavage; 8 days) shows ameliorative effects in a DSS -induced mouse colitis model[4].
In Vitro, Isoxanthohumol (0-100 μM; 20 min-6 d) reduces the viability, induces apoptosis of mature 3T3-L1 adipocytes, and inhibits the differentiation of 3T3-L1 preadipocytes. The mechanisms are associated with ROS generation and mitochondrial dysfunction[1]. Isoxanthohumol (2.5-50 µg/mL) inhibits Botrytis cinerea, Fusarium graminearum, and Sclerotinia sclerotiorum with EC50 values of 4.32, 16.50, and 14.52 µg/mL, respectively[2]. Isoxanthohumol (1.6-100 μM; 0-7 d) suppresses the proliferation, adhesion, migration, invasion, and colony formation, induces apoptosis and autophagy, and downregulates the integrin signaling pathway in B16-F10 cells[3].
References:
[1]. Yang JY, et al. Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis. Apoptosis. 2007 Nov;12(11):1953-63.
[2]. Yan YF, et al. The Antifungal Mechanism of Isoxanthohumol from Humulus lupulus Linn. Int J Mol Sci. 2021 Oct 7;22(19):10853.
[3]. Krajnović T, et al. The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model. Food Chem Toxicol. 2019 Jul;129:257-268.
[4]. Yang YN, et al. Therapeutic effects and mechanisms of isoxanthohumol on DSS-induced colitis: regulating T cell development, restoring gut microbiota, and improving metabolic disorders. Inflammopharmacology. 2024 Jun;32(3):1983-1998.
[5]. Żołnierczyk AK, et al. Isoxanthohumol--Biologically active hop flavonoid. Fitoterapia. 2015 Jun;103:71-82.