Isoliquiritigenin
Catalog No.: GN10088Purity:>98.00%Synonyms: GU 17, ILQ, ISL
Isoliquiritigenin is a flavonoid compound derived from licorice. Isoliquiritigenin can activate the Nrf2 pathway to reduce oxidative stress and inflammation, while also inhibiting cancer progression by inducing apoptosis.
المنتجات مخصصة للاستخدام البحثي فقط، وليست للاستخدام البشري. نحن لا نبيع للمرضى.
Cas No.: 961-29-5
10mM (in 1mL DMSO)In Stock
$35.00
1
5mgIn Stock
$20.00
1
10mgIn Stock
$32.00
1
50mgIn Stock
$63.00
1
100mgIn Stock
$98.00
1
200mgIn Stock
$147.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $35.00 | In Stock | 1 | |
| 5mg | $20.00 | In Stock | 1 | |
| 10mg | $32.00 | In Stock | 1 | |
| 50mg | $63.00 | In Stock | 1 | |
| 100mg | $98.00 | In Stock | 1 | |
| 200mg | $147.00 | In Stock | 1 |
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المراجع (Citations)
1 publicationsمنشورات الباحثين الذين استخدموا هذا المنتجالوصف (Description)
Isoliquiritigenin is a flavonoid compound derived from licorice. Isoliquiritigenin can activate the Nrf2 pathway to reduce oxidative stress and inflammation, while also inhibiting cancer progression by inducing apoptosis[1-2]. Isoliquiritigenin can also inhibit the activity of aldose reductase, neutralize free radicals to reduce oxidative damage, and is used in research related to the nervous system, antiviral, antitumor, and other areas[3-4].
In vitro, treatment of SK-MEL-28 human melanoma cells with Isoliquiritigenin (1–50µM) for 24–72 hours, Isoliquiritigenin significantly induced apoptosis and reduced cell viability by triggering the mitochondrial pathway (activating caspase-9/-7/-3, PARP cleavage, regulating the Bax/Bcl-2 balance, promoting cytochrome C release) and inhibiting the ROS-mediated p38/mTOR/STAT3 signaling pathway[5]. Treatment of NOZ and SGC-996 human gallbladder cancer cells with Isoliquiritigenin (20–100µM) for 24–72 hours, Isoliquiritigenin induced ferroptosis and inhibited cell proliferation by activating the p62-Keap1-Nrf2-HMOX1 axis, downregulating GPX4 expression, leading to iron accumulation, lipid peroxidation, and disruption of the GSH/GSSG ratio[6].
In vivo, intragastric administration of Isoliquiritigenin (5–20mg/kg/day) to ICR mice with cerebral ischemia-reperfusion injury (pretreated for 7 days, assessed 24 hours post-surgery), Isoliquiritigenin significantly reduced cerebral infarct volume and neurological deficits, and ameliorated oxidative stress and mitochondrial dysfunction by activating the Nrf2 pathway[7]. Intragastric administration of Isoliquiritigenin (20mg/kg/day) to high-fat diet-induced obese C57BL/6 mice (continued for 8 weeks), Isoliquiritigenin significantly reduced weight gain and white adipose tissue deposition, and activated the expression of thermogenesis-related genes in brown adipose tissue[8].
References:
[1] Chen Z, Ding W, Yang X, et al. Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases. J Ethnopharmacol. 2024 Jan 10;318(Pt B):117059.
[2] Qiu M, Ma K, Zhang J, et al. Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications. Front Pharmacol. 2024 Oct 9;15:1395735.
[3] Wang KL, Yu YC, Hsia SM. Perspectives on the Role of Isoliquiritigenin in Cancer. Cancers (Basel). 2021 Jan 1;13(1):115.
[4] Zhang Z, Yung KK, Ko JK. Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator. Antioxidants (Basel). 2022 Jul 11;11(7):1349.
[5] Kwon MJ, Raut PK, Jang JH, et al. Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells. Biomol Ther (Seoul). 2025 Mar 1;33(2):378-387.
[6] Wang Z, Li W, Wang X, et al. Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells. Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.
[7] Lan X, Wang Q, Liu Y, et al. Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway. Redox Biol. 2024 Nov;77:103406.
[8] Zhao L, Li M, Zhu Q, et al. Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue. Int J Mol Sci. 2025 Feb 14;26(4):1616.
البروتوكول (Protocol)
| Cell experiment [1]: | |
Cell lines | SK-MEL-28 cells (human melanoma cell line) |
Preparation Method | SK-MEL-28 cells were maintained in Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and antibiotics (100U/mL penicillin G and 100mg/mL streptomycin) at 37°C in a humidified incubator containing 5% CO₂. Cells were treated with Isoliquiritigenin at various concentrations (1, 25, and 50µM) for different durations (24, 48, and 72 hours). |
Reaction Conditions | 1–50μM; 24–72 hours |
Applications | Isoliquiritigenin treatment significantly reduced SK-MEL-28 cell viability in a concentration- and time-dependent manner, Isoliquiritigenin induced apoptosis in SK-MEL-28 cells, including caspase-9, -7, -3, and PARP. Isoliquiritigenin promoted mitochondrial pathway-mediated apoptosis, and stimulating the release of cytochrome C from the mitochondria into the cytosol. |
| Animal experiment [2]: | |
Animal models | ICR mice |
Preparation Method | Mice were pretreated with Isoliquiritigenin or vehicle (0.5% CMC-Na solution) by intragastric administration once a day for seven consecutive days. Subsequently, cerebral ischemia-reperfusion injury (CIRI) was induced by subjecting the mice to 2 hours of left middle cerebral artery occlusion (MCAO) followed by 24 hours of reperfusion. Mice were sacrificed after the reperfusion period for analysis. |
Dosage form | 5, 10, and 20mg/kg; i.g.; Once daily for 7 days. |
Applications | Isoliquiritigenin pretreatment significantly alleviated MCAO-induced cerebral infarction in a dose-dependent manner. The 20mg/kg dose was particularly effective, reduced the infarct volume to a level comparable to the positive control drug, Nimodipine. Isoliquiritigenin administration alleviated histopathological damage in the ischemic cerebral cortex and hippocampal regions. Isoliquiritigenin reduced neuronal loss, disordered arrangement, karyopyknosis, and interstitial swelling, while increasing the integrity of neurons and Nissl bodies. |
References: | |
وثائق المنتج (Product Documents)
Purity:>98.00%Appearance:A solid
الخصائص الكيميائية (Chemical Properties)
رقم CAS
961-29-5
المرادفات
GU 17, ILQ, ISL
الاسم الكيميائي
(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
SMILES
C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
الصيغة الجزيئية
C15H12O4
الوزن الجزيئي
256.25
الذوبانية
≥ 12.4mg/mL in DMSO
التخزين
Store at 2-8°C
إرشادات عامة
اختر مذيبًا مناسبًا وفقًا لبيانات ذوبانية المنتج. بعد التحضير، قسّم المحلول المخزون إلى أجزاء لتجنب دورات التجميد والذوبان المتكررة.
استخدم المحاليل المخزونة خلال 6 أشهر عند حفظها في -80°C، أو خلال شهر واحد عند حفظها في -20°C.
لتحسين الذوبانية، سخّن الأنبوب إلى 37°C وعرّضه للموجات فوق الصوتية لمدة مناسبة.
استخدم المحاليل المخزونة خلال 6 أشهر عند حفظها في -80°C، أو خلال شهر واحد عند حفظها في -20°C.
لتحسين الذوبانية، سخّن الأنبوب إلى 37°C وعرّضه للموجات فوق الصوتية لمدة مناسبة.
شروط الشحن
تُشحن عينات التقييم مع عبوات تبريد. وتُشحن الأحجام الأخرى المتاحة في درجة حرارة الغرفة، أو مع عبوات تبريد عند الطلب.
الحاسبات (Calculators)المولارية / التخفيف / الوزن الجزيئي / تحويل الوحدات / تركيبة داخل الجسم الحي / الذوبانية
g/mol
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