Parsaclisib (INCB050465) (Synonyms: INCB050465) |
| رقم الكتالوجGC32916 |
Parsaclisib (INCB050465) (INCB050465) هو مثبط فعال وانتقائي وفعال عن طريق الفم لـ PI3Kδ ؛ مع IC50 من 1 نانومتر عند 1 مم ATP. يُظهر Parsaclisib (INCB050465) انتقائية بمقدار 20000 ضعف تقريبًا على الأشكال الإسوية الأخرى من الفئة الأولى PI3K. يمكن استخدام بارساكليسيب (INCB050465) في البحث عن الأورام الخبيثة للخلايا البائية المنكسة أو المقاومة للعلاج.
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Cas No.: 1426698-88-5
Sample solution is provided at 25 µL, 10mM.
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Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
Parsaclisib (INCB050465) is a potent and selective PI3Kδ with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation aaasys. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM)[1].
[1]. Niu Shin, et al. Abstract 2671: INCB050465, a novel PI3Kδ inhibitor, synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. Cancer Research. 2015, Aug. 75(15).
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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