Castanospermine (Synonyms: 6,7Diepicastanospermine, 6Epicastanospermine, NSC 625381, 1,6,7,8Tetrahydroxyoctahydroindolizine) |
| رقم الكتالوجGC12950 |
يثبط Castanospermine جميع أشكال α- و-glucosidases ، وخاصة الجلوكوزيداز l (مطلوب لمعالجة بروتين الجلوكوز عن طريق نقل مانوز والجلوكوز من الدهون المرتبطة بالأسباراجين)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 79831-76-8
Sample solution is provided at 25 µL, 10mM.
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Castanospermine inhibits all forms of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids).target:α- and β-glucosidases.IC 50: 1.2 uM [2] in vitro :Castanospermine, [(1 S,6S,7R,8R,8aR)-1 ,6,7,8-tetrahydroxyoctahydroindolizine]is a potent and specific inhibitor of mammalian and plant α-and β-D-glucosidases in vitro [1] in vivo: Experiments in vivo with castanospermine, an inhibitor of the glucosidases that convert protein N-linked high mannose carbohydrates to complex oligosaccharides, resulted in significant inhibition of tumor growth in nude mice.[3]
References:
[1]. Bryan G, Anthony C et al. The structural basis of the inhibition of human glycosidases bycastanospermine analogues. Biochem. J. (1990) 269, 227-231.
[2]. Eisaku Tsujii et al. Nectrisine Is a Potent Inhibitor of a-Glucosidases, DemonstratingActivities Similarly at Enzyme and Cellular Levels. Biochemical and Biophysical Research Communications 220, 459-466 (1996)
[3]. Pili R et al. The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, preventsangiogenesis, and inhibits tumor growth. Cancer Res. 1995 Jul 1;55(13):2920-6.
| Cas No. | 79831-76-8 | SDF | |
| المرادفات | 6,7Diepicastanospermine, 6Epicastanospermine, NSC 625381, 1,6,7,8Tetrahydroxyoctahydroindolizine | ||
| Chemical Name | (1S,6S,7R,8R,8aR)-octahydroindolizine-1,6,7,8-tetraol | ||
| Canonical SMILES | O[C@@H]([C@@H]1O)[C@@H]2N(C[C@@H]1O)CC[C@@H]2O | ||
| Formula | C8H15NO4 | M.Wt | 189.21 |
| الذوبان | DMF: 0.1 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | Store at RT |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.2851 mL | 26.4257 mL | 52.8513 mL |
| 5 mM | 1.057 mL | 5.2851 mL | 10.5703 mL |
| 10 mM | 528.5 μL | 2.6426 mL | 5.2851 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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