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TSLP modulator-1

رقم الكتالوجGC79405 Copy One-Click Copy Product Info

TSLP modulator-1 (Compound 14O) is a potent TSLP signaling modulator.

Products are for research use only. Not for human use. We do not sell to patients.

TSLP modulator-1 التركيب الكيميائي

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
377٫00
متوفر
1mg
138٫00
متوفر
5mg
343٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


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بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.



Description of TSLP modulator-1

TSLP modulator-1 (Compound 14O) is a potent TSLP signaling modulator. TSLP modulator-1 exhibits potent inhibition of CCL17 and IL-1β mRNA expression. TSLP modulator-1 attenuates the protein levels of IL-6, IL-4 and IL-13. TSLP modulator-1 significantly attenuates calcium influx. TSLP modulator-1 exerts anti-inflammatory effects. TSLP modulator-1 effectively alleviates pruritus and atopic dermatitis-like symptoms [1].

References:
[1]. Seo KH, et al. Synthetic Strategy and Evaluation of the Benzyloxy Benzylamide Derivatives as Thymic Stromal Lymphopoietin Modulators for the Treatment of Atopic Dermatitis. J Med Chem. 2026 Jan 22;69(2):1154-1177.

Chemical Properties of TSLP modulator-1

Cas No. SDF
Formula C20H24ClF3N2O2 M.Wt 416.86
الذوبان DMSO: 70 mg/mL (167.92 mM; Need ultrasonic) Storage Store at -20°C
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of TSLP modulator-1

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.3989 mL 11.9944 mL 23.9889 mL
5 mM 479.8 μL 2.3989 mL 4.7978 mL
10 mM 239.9 μL 1.1994 mL 2.3989 mL
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In vivo Formulation Calculator (Clear solution) of TSLP modulator-1

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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