GLPBio

BI1071

Catalog No.: GC81690Purity:>98.50%
COASDSData Sheet
BI1071 is an orally active Nur77-Bcl-2 apoptotic pathway modulator.

Products are for research use only. Not for human use. We do not sell to patients.

BI1071
1mgIn Stock
$135.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
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    Nature
    641, 529–536 (2025)
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    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

BI1071 is an orally active Nur77-Bcl-2 apoptotic pathway modulator. BI1071 can bind to Nur77-LBD protein with a K d of 0.17 μM. BI1071 can activate Nur77 signaling and induce apoptosis by translocating to mitochondria where it interacts with Bcl-2. BI1071 can inhibit tumor growth in SW620 xenograft mice model. BI1071 can be used for research of colon cancer [1].

References:
[1]. Chen X, et al. BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway. Mol Cancer Ther. 2019 May;18(5):886-899.

Product Documents

Purity:>98.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C25H19F3N2O3S
Molecular Weight
484.49
Solubility
DMSO: 100 mg/mL (206.40 mM; Need ultrasonic)
Storage
Store at 4°C, sealed storage, away from moisture and light
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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