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Home >> Signaling Pathways >> Apoptosis >> Bcl-2 Family

Bcl-2 Family

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

Products for  Bcl-2 Family

  1. Cat.No. Product Name Information
  2. GC17008 (+)-Apogossypol

    inhibitor of Bcl-2 family proteins

     (+)-Apogossypol Chemical Structure
  3. GC34980 (E)-Ferulic acid (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid Chemical Structure
  4. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) Chemical Structure
  5. GC72991 (Rac)-Lisaftoclax

    (Rac)-APG-2575

     (Rac)-Lisaftoclax ((Rac)-APG-2575) is a Bcl-2 inhibitor that can be uesd for hematologic malignancy research (CN112898295A). (Rac)-Lisaftoclax Chemical Structure
  6. GC35001 (S)-Gossypol acetic acid

    (S)-(+)-Gossypol acetic acid

     (S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity. (S)-Gossypol acetic acid Chemical Structure
  7. GC73372 (S)-Sabutoclax

    (S)-BI-97C1

     (S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax Chemical Structure
  8. GC12258 2,3-DCPE hydrochloride 2,3-DCPE hydrochloride Chemical Structure
  9. GC17512 A-1155463 BCL-XL inhibitor, potent and selective A-1155463 Chemical Structure
  10. GC16278 A-1210477 MCL-1 inhibitor A-1210477 Chemical Structure
  11. GC17513 A-1331852 BCL-XL inhibitor, potent and selective A-1331852 Chemical Structure
  12. GC32981 A-385358 A-385358 is a selective inhibitor of Bcl-XL with Kis of 0.80 and 67 nM for Bcl-XL and Bcl-2, respectively. A-385358 Chemical Structure
  13. GC64674 ABBV-167 ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax. ABBV-167 Chemical Structure
  14. GC73269 ABBV-467 ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 Chemical Structure
  15. GC14069 ABT-199

    GDC 0199, Venetoclax

     Venetoclax (ABT-199, GDC-0199) is a selective inhibitor of Bcl-2 with a K i of 0.01 nM in cell-free assays. ABT-199 Chemical Structure
  16. GC12405 ABT-263 (Navitoclax)

    Navitoclax,ABT-263,ABT263,ABT 263

     ABT-263 (Navitoclax) is a inhibitor of Bcl-xL, Bcl-2 and Bcl-w, with Ki ≤0.5 nM, ≤1 nM and ≤1 nM respectively. ABT-263 (Navitoclax) Chemical Structure
  17. GC17234 ABT-737

    ABT 737, ABT737

     An inhibitor of anti-apoptotic Bcl-2 proteins ABT-737 Chemical Structure
  18. GN10341 Acetate gossypol Acetate gossypol Chemical Structure
  19. GC19452 AMG-176

    AMG-176

     AMG-176 (Tapotoclax) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM.  AMG-176 Chemical Structure
  20. GC14080 Apogossypolone (ApoG2)

    ApoG2

     Apogossypolone (ApoG2) Chemical Structure
  21. GC72803 Aspidin BB Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB Chemical Structure
  22. GC11106 AT-101 AT-101 Chemical Structure
  23. GC33247 AZD-5991 An Mcl-1 inhibitor AZD-5991 Chemical Structure
  24. GC33283 AZD-5991 Racemate AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay. AZD-5991 Racemate Chemical Structure
  25. GC33239 AZD-5991 S-enantiomer AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay. AZD-5991 S-enantiomer Chemical Structure
  26. GC33255 AZD4320 AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively. AZD4320 Chemical Structure
  27. GC72817 BAI1 hydrochloride BAI1 drochloride is a selective apoptosis factor BAX allosteric inhibitors. BAI1 hydrochloride Chemical Structure
  28. GC34263 Bak BH3 Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells. Bak BH3 Chemical Structure
  29. GC12053 BAM7

    BAM 7;BAM-7

     A direct activator of Bax BAM7 Chemical Structure
  30. GC68729 Bax activator-1

    Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent apoptosis in tumor cells.

     Bax activator-1 Chemical Structure
  31. GC12763 Bax channel blocker Bax channel blocker Chemical Structure
  32. GC16023 Bax inhibitor peptide P5 Bax inhibitor Bax inhibitor peptide P5 Chemical Structure
  33. GC17195 Bax inhibitor peptide V5

    BIP-V5; BAX Inhibiting Peptide V5

     A Bax inhibitor Bax inhibitor peptide V5 Chemical Structure
  34. GC16695 Bax inhibitor peptide, negative control Peptide inhibit Bax translocation to mitochondria Bax inhibitor peptide, negative control Chemical Structure
  35. GC71008 BBR-BODIPY BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY Chemical Structure
  36. GC63325 Bcl-xL antagonist 2 Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL). Bcl-xL antagonist 2 Chemical Structure
  37. GC62599 BCL6-IN-4 BCL6-IN-4 is a potent B-cell lymphoma 6 (BCL6) inhibitor with an IC50 of 97 nM. BCL6-IN-4 has anti-tumor activities. BCL6-IN-4 Chemical Structure
  38. GC68012 BCL6-IN-7 BCL6-IN-7 Chemical Structure
  39. GC10721 BDA-366 BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells. BDA-366 Chemical Structure
  40. GC73940 BFC1108 BFC1108 is a small molecule Bcl-2 functional converter. BFC1108 Chemical Structure
  41. GC74043 Bfl-1-IN-2 Bfl-1-IN-2 (Compound 13) is a reversible and covalent inhibitor of Bfl-1 (IC50: 4.3 μM). Bfl-1-IN-2 Chemical Structure
  42. GC18136 BH3I-1

    BHI1; BH 3I1

     Bcl-2 or Bcl-XL inhibitor BH3I-1 Chemical Structure
  43. GC15987 BIM, Biotinylated

    Bim peptide fragment with a biotin moiety attached

     BIM, Biotinylated Chemical Structure
  44. GC68765 Bim-IN-1

    Bim-IN-1 is an effective inhibitor of Bim expression. It can reduce the expression level of Bim without significantly inhibiting protein kinase A, and it also has low toxicity.

     Bim-IN-1 Chemical Structure
  45. GC33407 BM 957 BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, <1 nM and IC50s of 5.4, 6.0 nM respectively. BM 957 Chemical Structure
  46. GC13498 BM-1074 BM-1074 Chemical Structure
  47. GC62871 BM-1244

    APG-1252-M1

     BM-1244 (APG-1252-M1) is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1). BM-1244 Chemical Structure
  48. GC38014 BT2 An Mcl-1 inhibitor BT2 Chemical Structure
  49. GC31806 Bz 423 (BZ48)

    BZ48

     Bz 423 (BZ48) is a pro-apoptotic 1,4-benzodiazepine with therapeutic properties in murine models of lupus demonstrating selectivity for autoreactive lymphocytes, and activates Bax and Bak. Bz 423 (BZ48) Chemical Structure
  50. GC73935 CBI1 formic CBI1 formic is a covalent BAX inhibitor. CBI1 formic Chemical Structure
  51. GC62561 CCT369260 CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM. CCT369260 Chemical Structure
  52. GN10463 Chelerythrine Chelerythrine Chemical Structure
  53. GC13065 Chelerythrine Chloride

    Broussonpapyrine chloride, NSC 646662

     Potent inhibitor of PKC and Bcl-xL Chelerythrine Chloride Chemical Structure
  54. GN10219 Ciwujianoside-B Ciwujianoside-B Chemical Structure
  55. GC60111 Clitocine Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity. Clitocine Chemical Structure
  56. GN10040 Dehydrocorydaline Dehydrocorydaline Chemical Structure
  57. GC68956 Dehydrocorydaline (hydroxyl)

    13-Methylpalmatine (hydroxyl)

    Dehydrocorydaline hydroxyl (13-Methylpalmatine) is a type of alkaloid. It regulates the expression of Bax and Bcl-2 proteins, activates caspase-7 and caspase-8, and causes PARP inactivation. Dehydrocorydaline hydroxyl can enhance p38 MAPK activation, which has anti-inflammatory and anti-cancer effects. Dehydrocorydaline hydroxyl has a strong anti-malaria effect with low cytotoxicity (cell survival rate > 90%), particularly against the P. falciparum 3D7 strain (IC50=38 nM).

     Dehydrocorydaline (hydroxyl) Chemical Structure
  58. GC10661 Destruxin B

    SB 242536,NSC 236580

     insecticidal and phytotoxic activity;induces apoptosis Destruxin B Chemical Structure
  59. GC38617 Dihydrokaempferol

    (+)-Aromadendrin, (+)-Dihydrokaempferol, Dihydrokaempferol, trans-Dihydrokaempferol

     Dihydrokaempferol (Aromadendrin) is a naturally occurring flavonoid compound with biological activities such as free radical scavenging, anti-inflammatory and anti-tumor. Dihydrokaempferol Chemical Structure
  60. GC35882 dMCL1-2 dMCL1-2 is a potent and selective PROTAC of myeloid cell leukemia 1 (MCL1) (Bcl-2 family member) based on Cereblon, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1. dMCL1-2 Chemical Structure
  61. GC12139 Gambogic Acid

    GA, β-Guttiferin

     Gambogic Acid A cell-permeable caspase activator and apoptosis inducer commonly used in studies of breast, lung, and liver cancers. Gambogic Acid Chemical Structure
  62. GC32998 Ginsenoside Rh4 Ginsenoside Rh4 Chemical Structure
  63. GC69163 GL0388

    GL0388 is a Bax activator that induces the insertion of Bax into mitochondrial membranes. GL0388 exhibits anti-proliferative activity against various cancer cells with IC50 values ranging from 0.299-1.57 μM. GL0388 activates Bax and induces Bax-mediated apoptosis in cells. In vivo, GL0388 inhibits the growth of xenograft tumors in breast cancer.

     GL0388 Chemical Structure
  64. GC34134 Glycocholic acid

    Cholylglycine, GCA

     Glycocholic acid is a crystalline bile acid involved in fat emulsification. It is a combination of bile acid and glycine and exists in mammalian bile in the form of sodium salt. Glycocholic acid Chemical Structure
  65. GN10082 Gossypol

    BL 193, (±)-Gossypol, NSC 56817, NSC 624336, Pogosin

     Gossypol Chemical Structure
  66. GC11510 HA14-1 A Bcl-2 inhibitor HA14-1 Chemical Structure
  67. GC12046 iMAC2 iMAC2 Chemical Structure
  68. GN10645 Jaceosidin Jaceosidin Chemical Structure
  69. GC64467 Lisaftoclax

    APG-2575; Bcl-2/Bcl-xl inhibitor 1

     Lisaftoclax (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax Chemical Structure
  70. GC15480 Marinopyrrole A

    Marinopyrrole A

     Marinopyrrole A (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM). Marinopyrrole A Chemical Structure
  71. GC66017 Mcl-1 inhibitor 6 Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a Kd of 0.23 nM and a Ki of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, Kd>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent. Mcl-1 inhibitor 6 Chemical Structure
  72. GC38927 MCL-1/BCL-2-IN-2 MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor. MCL-1/BCL-2-IN-2 Chemical Structure
  73. GC38928 MCL-1/BCL-2-IN-3 MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively. MCL-1/BCL-2-IN-3 Chemical Structure
  74. GC36556 Mcl1-IN-1 Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 ?M). Mcl1-IN-1 Chemical Structure
  75. GC36557 Mcl1-IN-11 Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively. Mcl1-IN-11 Chemical Structure
  76. GC36558 Mcl1-IN-12 Mcl1-IN-12 (Compound F) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively. Anti-tumor activity. Mcl1-IN-12 Chemical Structure
  77. GC33035 Mcl1-IN-2 Mcl1-IN-2 is an inhibitor of myeloid cell factor 1 (Mcl-1). Mcl1-IN-2 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of Mcl1-IN-2 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively. Mcl1-IN-2 Chemical Structure
  78. GC33347 Mcl1-IN-3 Mcl1-IN-3 is an inhibitor of Mcl1 extracted from patent WO2015153959A2, compound example 57; has an IC50 and Ki of 0.67 and 0.13 μM, respectively. Mcl1-IN-3 Chemical Structure
  79. GC33364 Mcl1-IN-4 Mcl1-IN-4 is an inhibitor of Mcl1 with an IC50 of 0.2 μM. Mcl1-IN-4 Chemical Structure
  80. GC38811 Mcl1-IN-8 Mcl1-IN-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells. Mcl1-IN-8 Chemical Structure
  81. GC36559 Mcl1-IN-9 Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM. Mcl1-IN-9 Chemical Structure
  82. GC33295 MIK665 (S-64315)

    S64315

     MIK665 (S-64315) (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor. MIK665 (S-64315) has an IC50 of 1.81 nM for MCL1. MIK665 (S-64315) Chemical Structure
  83. GC15400 MIM1 An Mcl-1 inhibiting molecule MIM1 Chemical Structure
  84. GC33312 ML311 An Mcl-1 inhibitor ML311 Chemical Structure
  85. GC61096 MSN-125 MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity. MSN-125 Chemical Structure
  86. GC63083 MSN-50 MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 Chemical Structure
  87. GC16938 Muristerone A

    Mur A

     An ecdysteroid receptor agonist Muristerone A Chemical Structure
  88. GC62707 Murizatoclax

    AMG 397

     Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer. Murizatoclax Chemical Structure
  89. GC68019 NPB NPB Chemical Structure
  90. GC72835 NSC260594 NSC260594 induces Apoptosis. NSC260594 Chemical Structure
  91. GC25673 Obatoclax (GX15-070) Obatoclax (GX15-070) Chemical Structure
  92. GC11569 Obatoclax mesylate (GX15-070)

    GX15070

     An antagonist of pro-survival Bcl-2 proteins Obatoclax mesylate (GX15-070) Chemical Structure
  93. GC72892 Oblimersen sodium Oblimersen sodium is a BCL-2 inhibitor targeting BCL-2 RNA. Oblimersen sodium Chemical Structure
  94. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  95. GC62505 Pelcitoclax

    APG-1252

     Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects. Pelcitoclax Chemical Structure
  96. GC63769 PROTAC Bcl-xL degrader-2 PROTAC Bcl-xL degrader-2 is a potent Bcl-xL (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC50 of 0.6 nM. PROTAC Bcl-xL degrader-2 Chemical Structure
  97. GC38941 PROTAC Bcl2 degrader-1 PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. PROTAC Bcl2 degrader-1 Chemical Structure
  98. GC38943 PROTAC Mcl1 degrader-1 PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1 Chemical Structure
  99. GC34389 PUMA BH3 PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM. PUMA BH3 Chemical Structure
  100. GC12902 Pyridoclax

    MR-29072

     Mcl-1 inhibitor Pyridoclax Chemical Structure
  101. GC72864 PZ703b hydrochloride PZ703b drochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b hydrochloride Chemical Structure

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