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Bcl-2 Family

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

  1. Cat.No. Product Name Information
  2. GC17008 (+)-Apogossypol inhibitor of Bcl-2 family proteins
  3. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))
  4. GC35001 (S)-Gossypol acetic acid
  5. GC12258 2,3-DCPE hydrochloride

    2,3-DCPE is a proapoptotic compound with selectivity for cancer cells versus normal human cells

  6. GC17512 A-1155463 BCL-XL inhibitor, potent and selective
  7. GC16278 A-1210477
  8. GC17513 A-1331852 BCL-XL inhibitor, potent and selective
  9. GC32981 A-385358
  10. GC14069 ABT-199

    Bcl-2 inhibitor,potent and selective

  11. GC12405 ABT-263 (Navitoclax)

    Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w

  12. GC17234 ABT-737

    Bcl-2 inhibitor

  13. GN10341 Acetate gossypol Extracted from Gossypium herbaceum L. seeds and barks;Store the product in sealed, cool and dry condition
  14. GC19452 AMG-176

    AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor

  15. GC14080 Apogossypolone (ApoG2) Bcl-2 inhibitor,nonpeptidic small molecule
  16. GC11106 AT-101 BH3-mimetic,gossypol enantiomer
  17. GC33247 AZD-5991
  18. GC33283 AZD-5991 Racemate
  19. GC33239 AZD-5991 S-enantiomer
  20. GC33255 AZD4320
  21. GC34263 Bak BH3

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