GLPBio

BMS-P5

Catalog No.: GC48495Purity:>99.50%
COASDSData Sheet
BMS-P5 is a novel, orally active selective inhibitor of peptidylarginine deiminase 4 (PAD4) with an IC50 of 98nM.

Products are for research use only. Not for human use. We do not sell to patients.

BMS-P5
Cas No.: 1550371-22-6
10mM (in 1mL DMSO)In Stock
$123.00
1
1mgIn Stock
$33.00
1
5mgIn Stock
$119.00
1
10mgIn Stock
$209.00
1
25mgIn Stock
$355.00
1
50mgIn Stock
$513.00
1
100mgIn Stock
$727.00
1
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Description

BMS-P5 is a novel, orally active selective inhibitor of peptidylarginine deiminase 4 (PAD4) with an IC50 of 98nM. BMS-P5 blocks multiple myeloma-induced neutrophil extracellular trap (NET) formation. BMS-P5 can be used for research related to multiple myeloma[1-2].

In vivo, starting from day 3 after tumor cell injection, BMS-P5 (50mg/kg; twice daily) was administered by oral gavage to a multiple myeloma mouse model induced by DP42 cells for 20 days. BMS-P5 significantly delayed symptom development and prolonged survival[2].

References:
[1] Cîrciumaru A, Afonso MG, Wähämaa H, et al. Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation. Biomolecules. 2023 Mar 31;13(4):630.
[2] Li M, Lin C, Deng H, et al. A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Mol Cancer Ther. 2020 Jul;19(7):1530-1538.

Protocol

Animal experiment [1]:

Animal models

F1 progeny of mixed C57BL/6FVB/N background mice

Preparation Method

Multiple myeloma tumors were established by i.v. inoculation into the tail vein of DP42 cells (5×10³). Starting from the third day after tumor cell injection, BMS-P5 (50mg/kg; twice daily) was administered orally in a multiple myeloma mouse model induced by DP42 cells for 20 days.

Dosage form

50mg/kg; oral gavage; twice a day for 20 days

Applications

BMS-P5 administration significantly delayed development of symptoms (paralysis and hunched posture) and significantly prolonged survival of MM-bearing mice.

References:
[1] Li M, Lin C, Deng H, et al. A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Mol Cancer Ther. 2020 Jul;19(7):1530-1538.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1550371-22-6
SMILES
CN1C(C2=CC3=CC=CN=C3N2CC4CC4)=NC5=CC(C(N6[C@H](CC[C@H](C6)N)C)=O)=CC(OC)=C15
Molecular Formula
C27H32N6O2
Molecular Weight
472.6
Solubility
DMF: 20 mg/ml,DMSO: 5 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:8): 0.11 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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