PAD

Cl-Amidine (trifluoroacetate salt) is a multi-targeting peptidylarginine deminase (PAD) inhibitor with the functional group RC(NR)NR2 that inhibits PAD1 (IC 50 =0.8μM), PAD3 (IC 50 =6.2μM), and PAD4 (IC 50 =5.9μM) with 15min half-time.

Cl-amidine is an inhibitor of protein arginine deiminases (PAD; IC50s = 0.8, 6.2, and 5.9 uM for PAD1, PAD3, and PAD4 in vitro, respectively).

GSK484 is a selective PAD4 inhibitor, has been used as an anti-ischemic compound and exerts inhibitory activity against PAD4.

Streptonigrin (Bruneomycin) (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity.

BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.

Cl-amidine (N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide), is a PAD4 inactivator with enhanced potency.

BB-F-Yne is a cell-permeable derivative of the protein arginine diminase (PAD) inhibitor BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions.

CAY10723 is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity.

F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and PAD4 (IC50s = 29.5, 350, and 21.6 μM for PAD1, PAD3, and PAD4 in vitro, respectively).

GSK-121 Trifluoroacetates a selective PAD4 inhibitor.

GSK199 (hydrochloride) is an orally active and reversible selective peptidyl arginine deiminase 4 (PAD4) inhibitor with an IC 50 value of 200nM in the absence of calcium ions.

A PAD3 inhibitor

A PAD2 and PAD4 inhibitor

BMS-P5 is a novel, orally active selective inhibitor of peptidylarginine deiminase 4 (PAD4) with an IC 50 of 98nM.

A PAD2 inhibitor

GSK199 analog is an inhibitor of peptidyl arginine deiminase 4 (PAD4) and a derivative of the PAD4 inhibitor GSK199.