GLPBio

BRD7116

Catalog No.: GC12811Purity:>99.50%
COASDSData Sheet
inhibitor of leukemia stem cell activity

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BRD7116
Cas No.: 329059-55-4
10mM (in 1mL DMSO)In Stock
$40.00
1
10mgIn Stock
$36.00
1
25mgIn Stock
$72.00
1
50mgIn Stock
$117.00
1
100mgIn Stock
$198.00
1
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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

BRD7116, a bis-aryl sufone, acts as a selective inhibitor of leukemia stem cell activity by directly acting on the stromal cells to inhibit cobblestone formation [1,2].

BRD7116 displayed cell-non-autonomous anti-leukemia activity. In leukemia stem cells isolated from the bone marrow of leukemic animals in co-culture, BRD7116 exhibited an EC50 of 200 nM. BRD7116 displayed limited activity against normal HSPCs and AML cell lines with EC50s about 20 μM. BRD7116 showed activity against patient-derived primary human leukemia cells. Treatment of LSCe cells with BRD7116 induced transcriptional changes. The mechanism by which BRD7116 impaired the stroma’s ability to support leukemia cells has remained an important issue for future determination [1].

References:
[1] Hartwell K A, Miller P G, Mukherjee S, et al.  Niche-based screening identifies small-molecule inhibitors of leukemia stem cells[J]. Nature chemical biology, 2013, 9(12): 840-848.
[2] Sachlos E, Kerstetter-Fogle A.  Research Highlights: Highlights from the latest articles in regenerative medicine[J]. Regenerative medicine, 2014, 9(2): 145-147.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
329059-55-4
Chemical Name
N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide
SMILES
O=S(C1=CC=C(NC(C2C(C)(C)C2(C)C)=O)C=C1)(C3=CC=C(NC(C4C(C)(C)C4(C)C)=O)C=C3)=O
Molecular Formula
C28H36N2O4S
Molecular Weight
496.7
Solubility
≤10mg/ml in DMSO;10mg/ml in dimethyl formamide
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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