Calpains
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Calpains (calcium-dependent papain-like enzymes) are a family of intracellular enzymes that consist of complex multi-domains and share a calcium-dependent cysteine protease core. With the development of human genome sequencing, a total of fifteen human calpain genes have been identified (CAPN1 to CAPN15). Calpain 1 (μ-calpain) and calpain 2 (m-calpain) are the two most abundant and well studied members of calpain family in mammals, which are heterodimers characterized by consisting of an isoform-specific large subunit (approximately 80 kDa) and a common small subunit (approximately 28 kDa). The large subunit consists of four domains, domain I (function not clear), domain II (cysteine protease domain), domain III (function not clear) and domain IV (Ca2+-binding domain); while the small subunit consists of two domains, domain V (N-terminal glycine-clustering hydrophobic region) and domain VI (C-terminal Ca2+-binding domain).
Products Related to Calpains(11)
- GC10342CalpeptinCAS: 117591-20-5Purity: >98.00%
Calpeptin is a reversible and cell-permeable cysteine cathepsin inhibitor. The ID 50 values of Calpeptin for calpain I and II (porcine), papain, and platelet calpain I are 52nM, 34nM, 138nM, and 20nM, respectively. Calpeptin alleviates apoptosis and secondary inflammatory changes in muscle cells.
- GC12479Calpain Inhibitor XIICAS: 181769-57-3Purity: >98%
Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM).
- GC12527MG-101 (Calpain Inhibitor I, ALLN)CAS: 110044-82-1Purity: >98.00%
MG-101 (Calpain Inhibitor I, ALLN) also known as Calpain Inhibitor I, selectively inhibits various cysteine proteases, including calpain I, calpain II, cathepsin B, and cathepsin L. The corresponding Ki values for these enzymes are 90pM, 220pM, 150pM, and 500pM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10342 | Calpeptin | 117591-20-5 | >98.00% | |
Calpeptin is a reversible and cell-permeable cysteine cathepsin inhibitor. The ID 50 values of Calpeptin for calpain I and II (porcine), papain, and platelet calpain I are 52nM, 34nM, 138nM, and 20nM, respectively. Calpeptin alleviates apoptosis and secondary inflammatory changes in muscle cells. | ||||
| GC10383 | MG-132 | 133407-82-6 | >98.00% | |
MG-132 is a potent proteasome and calpain inhibitor with IC 50 values of 100nM and 1.25μM, respectively. | ||||
| GC11640 | MDL 28170 | 88191-84-8 | >97.00% | |
MDL 28170, a cell permeable, reversible, peptidic aldehyde inhibitor of calpain (K i = 0.01μM; K i for cathepsin B = 0.025μM). | ||||
| GC12152 | Acetyl-Calpastatin (184-210) (human) | 123714-50-1 | >98% | |
| GC12479 | Calpain Inhibitor XII | 181769-57-3 | >98% | |
Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). | ||||
| GC12527 | MG-101 (Calpain Inhibitor I, ALLN) | 110044-82-1 | >98.00% | |
MG-101 (Calpain Inhibitor I, ALLN) also known as Calpain Inhibitor I, selectively inhibits various cysteine proteases, including calpain I, calpain II, cathepsin B, and cathepsin L. The corresponding Ki values for these enzymes are 90pM, 220pM, 150pM, and 500pM. | ||||
| GC13418 | E-64 | 66701-25-5 | >99.00% | |
E-64 is a potent and irreversible inhibitor of cysteine proteases with an IC 50 of 9nM for papain. | ||||
| GC13450 | PD 145305 | 90536-15-5 | >98% | |
selective inhibitor of calpains | ||||
| GC15066 | Z-FA-FMK | 197855-65-5 | >98.50% | |
An inhibitor of cysteine proteases, including cathepsin B | ||||
| GC16383 | Calpain Inhibitor II, ALLM | 136632-32-1 | >98% | |
Calpain inhibitor | ||||
| GC16912 | PD 150606 | 179528-45-1 | >98.00% | |
An inhibitor of calpains | ||||