Inhibitors of cyclooxygenase (COX) are generally grouped according to selectivity for COX-1 versus COX-2. However, many COX inhibitors also show an antitumor, pro-apoptotic activity that is distinct from COX inhibition - celecoxib is an example. CAY10452 is a celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM), but does not induce apoptosis in prostate cancer cell lines even at 100 uM. CAY10452 is thus a clean, selective tool for the inhibition of COX-2.
CAY10452
Catalog No.: GC18427Purity:>99.50%Synonyms: PTPBS
CAY10452 (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 170569-87-6
10mM (in 1mL DMSO)In Stock
$50.00
1
5mgIn Stock
$28.00
1
10mgIn Stock
$45.00
1
25mgIn Stock
$81.00
1
50mgIn Stock
$135.00
1
100mgIn Stock
$225.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $50.00 | In Stock | 1 | |
| 5mg | $28.00 | In Stock | 1 | |
| 10mg | $45.00 | In Stock | 1 | |
| 25mg | $81.00 | In Stock | 1 | |
| 50mg | $135.00 | In Stock | 1 | |
| 100mg | $225.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>99.50%Appearance:A solid
Chemical Properties
CAS No.
170569-87-6
Synonyms
PTPBS
Chemical Name
4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
SMILES
FC(F)(F)C1=NN(C2=CC=C(S(=O)(N)=O)C=C2)C(C3=CC=CC=C3)=C1
Molecular Formula
C16H12F3N3O2S
Molecular Weight
367.3
Solubility
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:8): .1 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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