GLPBio

CCKBR agonist-1

Catalog No.: GC79302Purity:>98.00%
COASDSData Sheet
CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor ( CCKBR ) agonist with an EC 50 of 35 pM.

Products are for research use only. Not for human use. We do not sell to patients.

CCKBR agonist-1
Cas No.: 2923120-30-1
5mgIn Stock
$76.00
1
10mgIn Stock
$119.00
1
25mgIn Stock
$189.00
1
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Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor ( CCKBR ) agonist with an EC 50 of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC 50 of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase ( ADAM10 ) and calcium signaling molecule PLCB4, reduce the number of amyloid β ( Aβ ) plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimer's disease [1].

References:
[1]. Wang JL, et al. Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment. Cell. 2025 Nov 20:S0092-8674(25)01238-3.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2923120-30-1
Molecular Formula
C32H39BrN6O7
Molecular Weight
699.59
Solubility
DMSO: ≥ 50 mg/mL (71.47 mM)
Storage
Sealed storage, away from moisture
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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