CGRP

Reversible cholinesterase inhibitor

CGRP 8-37 (rat) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.

MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.

A CGRP receptor antagonist

CGRP 8-37 (human)is a highly selective CGRP receptor antagonists.

A CGRP receptor antagonist

Olcegepant is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor.

Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM).

Ubrogepant (MK-1602) (MK-1602) is a novel oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine.

CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively.

Adrenomedullin (AM) (22-52), human, is a NH2-terminal truncated forms of Adrenomedullin, which don’t possess the six-membered ring structure or retain the hypotensive and vasodilator activity.

Calcitonin salmon (Salmon calcitonin) is a calcitonin drug derived from salmon.

β-CGRP, human is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

Adrenomedullin (1-50), rat is a 50-amino acid polypeptide that induces selective arterial vasodilation by activating the calcitonin gene-related peptide 1 (CGRP1) receptor.

β-CGRP, human TFA is a neuropeptide hormone produced by the calcitonin gene-related peptide family, which forms a complex with calcitonin receptor-like receptors CRLR and RAMP (CRLR/RAMP1: IC 50 =1nM; CRLR/RAMP2: IC 50 = 300nM).

Adrenomedullin (11-50), rat is the C-terminal fragment (11-50) of rat adrenomedullin.

Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and with a Ki of 14.4 pM for human CGRP.

Endogenous calcitonin agonist; inhibits bone resorption

Vazegepant (BHV-3500) hydrochloride is a highly soluble CGRP receptor antagonist (hCGRP Ki= 0.023 nM).

Atogepant (MK-8031) is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist.

Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research.