GLPBio

CK 869

Catalog No.: GC15076Purity:>99.50%Synonyms: CK-0157869
COASDSData Sheet
actin-related protein 2/3 (Arp2/3) complex inhibitor

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CK 869
Cas No.: 388592-44-7
10mM (in 1mL DMSO)In Stock
$54.00
1
1mgIn Stock
$19.00
1
5mgIn Stock
$49.00
1
10mgIn Stock
$67.00
1
25mgIn Stock
$106.00
1
50mgIn Stock
$144.00
1
100mgIn Stock
$194.00
1
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Citations

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM[1]. CK-869 significantly inhibits MT polymerization even at a concentration of 25 μM[2].

References:
[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.
[2]. Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 2018 Feb 12;496(3):834-839.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
388592-44-7
Synonyms
CK-0157869
Chemical Name
2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one
SMILES
COC1=CC(OC)=C(N2C(CSC2C3=CC(Br)=CC=C3)=O)C=C1
Molecular Formula
C17H16BrNO3S
Molecular Weight
394.28
Solubility
DMF: 1.5 mg/ml,DMSO: 2.5 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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