Col003 |
| Catalog No.GC34539 |
Col003 is a selective and potent inhibitor of?Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 328565-16-8
Sample solution is provided at 25 µL, 10mM.
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Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix[1]. HSP47|1.8 μM (IC50)
[1]. Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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