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Home >> Signaling Pathways >> Proteases >> HSP

HSP

Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.

Products for  HSP

  1. Cat.No. Product Name Information
  2. GC63796 116-9e 116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e Chemical Structure
  3. GC11720 17-AAG (KOS953) An inhibitor of Hsp90 17-AAG (KOS953) Chemical Structure
  4. GC17210 17-AAG Hydrochloride Hsp90 inhibitor,geldanamycin analogue 17-AAG Hydrochloride Chemical Structure
  5. GC41955 17-DMAG 17-DMAG (17-DMAG) is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. 17-DMAG Chemical Structure
  6. GC13044 17-DMAG (Alvespimycin) HCl 17-DMAG (Alvespimycin) HCl (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM. 17-DMAG (Alvespimycin) HCl Chemical Structure
  7. GC61582 3-Phenyltoxoflavin 3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity. 3-Phenyltoxoflavin Chemical Structure
  8. GC61563 Aminohexylgeldanamycin Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities. Aminohexylgeldanamycin Chemical Structure
  9. GC39477 AMP-PCP disodium

    AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90.

     AMP-PCP disodium Chemical Structure
  10. GC65035 Apatorsen Apatorsen?is?an?antisense?oligonucleotide?designed?to?bind?to?Hsp27?mRNA,?resulting?in?the?inhibition of?the?production?of?Hsp27?protein. Apatorsen Chemical Structure
  11. GC14411 Apoptozole inhibitor of heat shock protein 70 (Hsp70) Apoptozole Chemical Structure
  12. GC31103 Arimoclomol maleate (BRX-220) Arimoclomol maleate (BRX-220) (BRX-220) is a co-inducer of heat shock proteins (HSP). Arimoclomol maleate (BRX-220) Chemical Structure
  13. GC13414 AT13387 AT13387 (AT13387) is a long-acting second-generation Hsp90 inhibitor with a Kd of 0.71 nM. AT13387 Chemical Structure
  14. GC15295 AUY922 (NVP-AUY922) An Hsp90 inhibitor AUY922 (NVP-AUY922) Chemical Structure
  15. GC41532 Benzisoxazole Hsp90 Inhibitor Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Benzisoxazole Hsp90 Inhibitor Chemical Structure
  16. GC12218 BIIB021 A potent, orally-available Hsp90 inhibitor BIIB021 Chemical Structure
  17. GC32620 Bimoclomol Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases. Bimoclomol Chemical Structure
  18. GC50153 BIX BIX, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BIX Chemical Structure
  19. GC65318 BOLD-100 BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution. BOLD-100 Chemical Structure
  20. GC10223 CCT018159 inhibitor of the ATPase activity of Hsp90 CCT018159 Chemical Structure
  21. GC19094 CCT251236 CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. CCT251236 Chemical Structure
  22. GC17822 CH5138303 Hsp90 inhibitor, orally available CH5138303 Chemical Structure
  23. GC34539 Col003

    Col003 is a selective and potent inhibitor of?Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM).

     Col003 Chemical Structure
  24. GC18832 Conglobatin Conglobatin is a dimeric macrolide dilactone originally isolated from S. Conglobatin Chemical Structure
  25. GC35757 Cucurbitacin D Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity. Cucurbitacin D Chemical Structure
  26. GC62305 DDO-5936 DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer. DDO-5936 Chemical Structure
  27. GC19121 Debio 0932 Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively. Debio 0932 Chemical Structure
  28. GC38223 Dihydroberberine Dihydroberberine Chemical Structure
  29. GC62120 DTHIB DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research. DTHIB Chemical Structure
  30. GC14776 EC 144 High affinity, potent and selective Hsp90 inhibitor EC 144 Chemical Structure
  31. GC13885 Elesclomol (STA-4783)

    An apoptosis inducer

     Elesclomol (STA-4783) Chemical Structure
  32. GC32965 Ethoxyquin An antioxidant used in animal feed Ethoxyquin Chemical Structure
  33. GC43649 Falcarinol

    Falcarinol is a C17-polyacetylene produced by the Apiaceae family that has antimicrobial properties due to its inhibition of fatty acid biosynthesis.

     Falcarinol Chemical Structure
  34. GC32008 Feretoside Feretoside, a phenolic compound extracted from the barks of E. Feretoside Chemical Structure
  35. GC17655 Ganetespib (STA-9090) Ganetespib (STA-9090) Chemical Structure
  36. GC10881 Gedunin naturally occurring Hsp90 inhibitor Gedunin Chemical Structure
  37. GC16361 Geldanamycin Binds Hsp90 and GRP94, inhibits growth of cancer cells Geldanamycin Chemical Structure
  38. GC64795 Geldanamycin-FITC Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC Chemical Structure
  39. GC64988 Grp94 Inhibitor-1 Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α. Grp94 Inhibitor-1 Chemical Structure
  40. GC19188 HA15 HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15 Chemical Structure
  41. GC40724 Heat Shock Protein Inhibitor II Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Heat Shock Protein Inhibitor II Chemical Structure
  42. GC61784 HS-27 HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer. HS-27 Chemical Structure
  43. GC32437 HSF1A HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1). HSF1A Chemical Structure
  44. GC38503 HSP27 inhibitor J2

    HSP27 inhibitor J2 (J2) is an inhibitor of HSP27, which significantly induces abnormal HSP27 dimer formation and inhibits HSP27 macropolymer production[1-3].

     HSP27 inhibitor J2 Chemical Structure
  45. GC32869 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. HSP70-IN-1 Chemical Structure
  46. GC68450 Hsp90-IN-17 hydrochloride Hsp90-IN-17 hydrochloride Chemical Structure
  47. GC11973 HSP990 (NVP-HSP990) HSP990 (NVP-HSP990) is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. HSP990 (NVP-HSP990) Chemical Structure
  48. GC63282 Icapamespib Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5?nM. Icapamespib Chemical Structure
  49. GC11391 IPI-504 (Retaspimycin hydrochloride) IPI-504 (Retaspimycin hydrochloride) Chemical Structure
  50. GC34634 JG-98 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. JG-98 Chemical Structure
  51. GC11930 KNK437 stress-induced HSP synthesis inhibitor KNK437 Chemical Structure
  52. GC64370 Kongensin A Kongensin A is a natural product isolated from Croton kongensis. Kongensin A Chemical Structure
  53. GC19215 KRIBB11 KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 uM. KRIBB11 Chemical Structure
  54. GC31118 KU-32 KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death. KU-32 Chemical Structure
  55. GC14636 KW-2478 An Hsp90 inhibitor KW-2478 Chemical Structure
  56. GC15042 Macbecin I Macbecin I is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin I exhibits antitumor and cytocidal activities. Macbecin I Chemical Structure
  57. GC12301 Mizoribine DNA/RNA synthesis inhibitor Mizoribine Chemical Structure
  58. GC17751 MKT 077 mortalin-2 (mot-2) inhibitor MKT 077 Chemical Structure
  59. GC18170 ML-346

    ML-346 is an activator of the heat shock response that induces the expression of the heat shock proteins HSP70, HSP40, and HSP27.

     ML-346 Chemical Structure
  60. GC14322 MPC-3100 An inhibitor of Hsp90 MPC-3100 Chemical Structure
  61. GC64714 NCT-58 NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells. NCT-58 Chemical Structure
  62. GC45926 Nelfinavir-d3 An internal standard for the quantification of nelfinavir Nelfinavir-d3 Chemical Structure
  63. GC13105 NMS-E973 Hsp90 inhibitor,potent and selective NMS-E973 Chemical Structure
  64. GC11179 NVP-BEP800 An Hsp90 inhibitor NVP-BEP800 Chemical Structure
  65. GC64655 NXP800 NXP800 (CCT361814) is a potent heat shock factor 1 (HSF1) inhibitor. NXP800 has?the?potential?for?cancer research. NXP800 Chemical Structure
  66. GC36834 p5 Ligand for Dnak and DnaJ p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ Chemical Structure
  67. GC63852 Palmitic acid-d3 Palmitic acid-d3 Chemical Structure
  68. GC67916 Palmitic acid-d4 Palmitic acid-d4 Chemical Structure
  69. GC11912 PF-04929113 (SNX-5422)

    Hsp90 inhibitor,potent and selective

     PF-04929113 (SNX-5422) Chemical Structure
  70. GC69777 PU-H54

    PU-H54 is a selective inhibitor of Grp94, which can be used for the study of breast cancer. The Hsp90 chaperone family includes Hsp90α, Hsp90β, Grp94 and Trap-1, which play important roles in malignant tumors.

     PU-H54 Chemical Structure
  71. GC15143 PU-H71 Hsp90 inhibitor,potent and selective PU-H71 Chemical Structure
  72. GC37040 PU-H71 hydrochloride PU-H71 hydrochloride Chemical Structure
  73. GC13307 PU-WS13

    Grp94-specific Hsp90 inhibitor

     PU-WS13 Chemical Structure
  74. GC11403 Radicicol An inhibitor of Hsp90 Radicicol Chemical Structure
  75. GC10327 Retaspimycin Retaspimycin Chemical Structure
  76. GC19548 Rocaglamide

    Rocaglamide is a potent NF-κB activation inhibitor.

     Rocaglamide Chemical Structure
  77. GC33426 Rocaglamide (Rocaglamide A)

    Rocaglamide (Rocaglamide A) is isolated from the genus Aglaia (family Meliaceae). 

     Rocaglamide (Rocaglamide A) Chemical Structure
  78. GC64685 SNX-0723 SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 Chemical Structure
  79. GC13946 SNX-2112 A potent Hsp90 inhibitor SNX-2112 Chemical Structure
  80. GC33047 SNX-5422 Mesylate (PF-04929113 (Mesylate)) SNX-5422 Mesylate (PF-04929113 (Mesylate)) Chemical Structure
  81. GC17901 Tamoxifen Tamoxifen(TAM) serves as a selective estrogen receptor regulator (SERM), inhibiting estrogen's effects in breast cells while potentially stimulating estrogen activity in cells found in different tissues. Tamoxifen Chemical Structure
  82. GC11669 Tamoxifen Citrate Antiestrogen drug Tamoxifen Citrate Chemical Structure
  83. GC48124 Tamoxifen-d5 An internal standard for the quantification of tamoxifen Tamoxifen-d5 Chemical Structure
  84. GC33286 TAS-116 TAS-116 (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity. TAS-116 Chemical Structure
  85. GC33663 Teprenone (Geranylgeranylacetone) Teprenone (Geranylgeranylacetone) is an anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs). Teprenone (Geranylgeranylacetone) Chemical Structure
  86. GC10481 TRC 051384 HSP70 inducer TRC 051384 Chemical Structure
  87. GC16966 VER 155008 An Hsp70 inhibitor VER 155008 Chemical Structure
  88. GC13556 VER-49009 HSP90 inhibitor, potent and selective VER-49009 Chemical Structure
  89. GC10501 VER-50589 HSP90 inhibitor, potent VER-50589 Chemical Structure
  90. GC16892 XL-888 An orally bioavailable Hsp90 inhibitor XL-888 Chemical Structure
  91. GC62388 YUM70 YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model. YUM70 Chemical Structure
  92. GC66059 YZ129 YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration. YZ129 Chemical Structure

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