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Home >> Signaling Pathways >> Proteases >> HSP

HSP

Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.

Products for  HSP

  1. Cat.No. Product Name Information
  2. GC63796 116-9e

    MAL2-11B

     116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e Chemical Structure
  3. GC11720 17-AAG (KOS953)

    BMS 722782, CP 127374, KOS 953, NSC 330507, Tanespimycin

     17-AAG (KOS953) is a potent Hsp90 inhibitor (IC50=5nM). 17-AAG (KOS953) Chemical Structure
  4. GC17210 17-AAG Hydrochloride

    Tanespimycin Hydrochloride;NSC 330507 Hydrochloride;CP 127374 Hydrochloride;17AAG Hydrochloride;17 AAG Hydrochloride

     Hsp90 inhibitor,geldanamycin analogue 17-AAG Hydrochloride Chemical Structure
  5. GC41955 17-DMAG

    Alvespimycin, KOS1022, NSC 707545

     17-DMAG (17-DMAG) is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. 17-DMAG Chemical Structure
  6. GC13044 17-DMAG (Alvespimycin) HCl 17-DMAG (Alvespimycin) HCl is an effective inhibitor of Hsp90, with an IC50 value of 62nM. 17-DMAG (Alvespimycin) HCl Chemical Structure
  7. GC90840 2-Chloroadenosine-5'-O-diphosphate (sodium salt)

    A derivative of ADP

     2-Chloroadenosine-5'-O-diphosphate (sodium salt) Chemical Structure
  8. GC61582 3-Phenyltoxoflavin 3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity. 3-Phenyltoxoflavin Chemical Structure
  9. GC61563 Aminohexylgeldanamycin

    AHGDM

     Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities. Aminohexylgeldanamycin Chemical Structure
  10. GC39477 AMP-PCP disodium

    AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90.

     AMP-PCP disodium Chemical Structure
  11. GC65035 Apatorsen

    OGX-427

    Apatorsen?is?an?antisense?oligonucleotide?designed?to?bind?to?Hsp27?mRNA,?resulting?in?the?inhibition of?the?production?of?Hsp27?protein.

     Apatorsen Chemical Structure
  12. GC14411 Apoptozole

    Apoptosis Activator VII

     Apoptozole is a small inhibitor targets HSC70 and HSP72, with the KD values of 210nM and 140nM, respectively. Apoptozole Chemical Structure
  13. GC31103 Arimoclomol maleate (BRX-220)

    BRX-220

     Arimoclomol maleate (BRX-220) (BRX-220) is a co-inducer of heat shock proteins (HSP). Arimoclomol maleate (BRX-220) Chemical Structure
  14. GC68703 AT-533

    AT-533 is an effective inhibitor of Hsp90 and HSV. It inhibits tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits downstream pathway activation, including Akt/mTOR/p70S6K, Erk1/2, and FAK. AT-533 suppresses tube formation, cell migration, and invasion in human umbilical vein endothelial cells (HUVEC).

     AT-533 Chemical Structure
  15. GC13414 AT13387

    AT-13387,Onalespib

     AT13387 is a small-molecule, non-ansamycin HSP90 (heat shock protein 90) inhibitor that acts by targeting the AKT and ERK signaling pathways. AT13387 Chemical Structure
  16. GC15295 AUY922 (NVP-AUY922)

    VER-52296, AUY-922, AUY 922, Luminespib

     AUY922 (NVP-AUY922) is a potent and selective inhibitor of HSP90, effectively inhibiting both HSP90α and HSP90β with similar IC50 values of 13nM and 21nM, respectively. AUY922 (NVP-AUY922) Chemical Structure
  17. GC72078 Azadiradione Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione Chemical Structure
  18. GC41532 Benzisoxazole Hsp90 Inhibitor

    BHI

     Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Benzisoxazole Hsp90 Inhibitor Chemical Structure
  19. GC12218 BIIB021

    CNF2024

     A potent, orally-available Hsp90 inhibitor BIIB021 Chemical Structure
  20. GC32620 Bimoclomol Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases. Bimoclomol Chemical Structure
  21. GC50153 BIX

    BiP Inducer X

     BIX, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BIX Chemical Structure
  22. GC65318 BOLD-100

    NKP-1339 free base; IT-139 free base; KP-1339 free base

     BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 Chemical Structure
  23. GC10223 CCT018159 inhibitor of the ATPase activity of Hsp90 CCT018159 Chemical Structure
  24. GC19094 CCT251236 CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. CCT251236 Chemical Structure
  25. GC17822 CH5138303 Hsp90 inhibitor, orally available CH5138303 Chemical Structure
  26. GC34539 Col003

    Col003 is a selective and potent inhibitor of?Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM).

     Col003 Chemical Structure
  27. GC18832 Conglobatin Conglobatin is a dimeric macrolide dilactone originally isolated from S. Conglobatin Chemical Structure
  28. GC35757 Cucurbitacin D

    (+)-Cucurbitacin D, Elatericin A, NSC 308606, NSC 521776

     Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity. Cucurbitacin D Chemical Structure
  29. GC62305 DDO-5936 DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer. DDO-5936 Chemical Structure
  30. GC19121 Debio 0932

    CUDC-305

     Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively. Debio 0932 Chemical Structure
  31. GC38223 Dihydroberberine Dihydroberberine is a potent haematopoietic prostaglandin D2 synthase (H-PGDS), with an IC50 value of 3.7µM. Dihydroberberine Chemical Structure
  32. GC62120 DTHIB DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research. DTHIB Chemical Structure
  33. GC14776 EC 144 High affinity, potent and selective Hsp90 inhibitor EC 144 Chemical Structure
  34. GC13885 Elesclomol (STA-4783)

    NSC 174939, STA 4783

     Elesclomol (also known as STA-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ROS) and the induction of unmanageable levels of oxidative stress. Elesclomol (STA-4783) Chemical Structure
  35. GC32965 Ethoxyquin

    NSC 6795

     An antioxidant used in animal feed Ethoxyquin Chemical Structure
  36. GC43649 Falcarinol Falcarinol is a naturally derived, orally active Hsp90 inhibitor. Falcarinol Chemical Structure
  37. GC32008 Feretoside Feretoside, a phenolic compound extracted from the barks of E. Feretoside Chemical Structure
  38. GC91152 Flavokawain 1i

    A flavokawain derivative with anticancer and antiviral activities

     Flavokawain 1i Chemical Structure
  39. GC33030 Gamitrinib TPP Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial-targeted HSP90 inhibitor with anticancer activity used to chemically interfere with mitochondrial protein folding and induce mitophagy. Gamitrinib TPP Chemical Structure
  40. GC17655 Ganetespib (STA-9090)

    STA9090, STA 9090

     Ganetespib (STA-9090) Chemical Structure
  41. GC10881 Gedunin

    NSC 113497

     naturally occurring Hsp90 inhibitor Gedunin Chemical Structure
  42. GC16361 Geldanamycin

    NSC 122750

     Binds Hsp90 and GRP94, inhibits growth of cancer cells Geldanamycin Chemical Structure
  43. GC64795 Geldanamycin-FITC Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC Chemical Structure
  44. GC73388 GRP78-IN-3 GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 Chemical Structure
  45. GC64988 Grp94 Inhibitor-1 Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α. Grp94 Inhibitor-1 Chemical Structure
  46. GC19188 HA15 HA15 is a molecule that specifically targets BiP/GRP78/HSPA5, binding to and inhibiting its ATPase activity, which leads to the dissociation of BiP from PERK, IRE1α, and ATF6, thereby triggering endoplasmic reticulum stress. HA15 Chemical Structure
  47. GC40724 Heat Shock Protein Inhibitor II

    Hsp Inhibitor II, KNK 423

     Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Heat Shock Protein Inhibitor II Chemical Structure
  48. GC72637 Hexadecanoate-13C16 potassium Hexadecanoate-13C16 (potassium) is the 13C-labeled Hexadecanoate sodium. Hexadecanoate-13C16 potassium Chemical Structure
  49. GC61784 HS-27 HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer. HS-27 Chemical Structure
  50. GC32437 HSF1A HSF1A is an activator of Heat Shock Transcription Factor 1 (HSF1). HSF1A Chemical Structure
  51. GC38503 HSP27 inhibitor J2

    J2

     HSP27 inhibitor J2 (J2) is an inhibitor of HSP27, which significantly induces abnormal HSP27 dimer formation and inhibits HSP27 macropolymer production. HSP27 inhibitor J2 Chemical Structure
  52. GC32869 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. HSP70-IN-1 Chemical Structure
  53. GC68450 Hsp90-IN-17 hydrochloride Hsp90-IN-17 hydrochloride Chemical Structure
  54. GC73701 HSP90-IN-27 HSP90-IN-27 (compound 19) is an HSP90 inhibitor. HSP90-IN-27 Chemical Structure
  55. GC11973 HSP990 (NVP-HSP990)

    NVP-HSP990

     HSP990 (NVP-HSP990) is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. HSP990 (NVP-HSP990) Chemical Structure
  56. GC63282 Icapamespib

    PU-HZ151

     Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5?nM. Icapamespib Chemical Structure
  57. GC73962 iHSP110-33

    iHSP110-33 is an inhibitor for heat shock protein 110 (HSP110).

     iHSP110-33 Chemical Structure
  58. GC11391 IPI-504 (Retaspimycin hydrochloride) IPI-504 (Retaspimycin hydrochloride) Chemical Structure
  59. GC69312 JG-231

    JG-231 is a JG-98 analogue with anti-cancer properties. It can inhibit the interaction between Hsp70-BAG3. JG-231 has an inhibitory effect on the MDA-MB-231 xenograft model of triple-negative breast cancer (TNBC).

     JG-231 Chemical Structure
  60. GC34634 JG-98 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. JG-98 Chemical Structure
  61. GC11930 KNK437

    Hsp Inhibitor I, KNK 437

     stress-induced HSP synthesis inhibitor KNK437 Chemical Structure
  62. GC64370 Kongensin A Kongensin A is a natural product isolated from Croton kongensis. Kongensin A Chemical Structure
  63. GC19215 KRIBB11 KRIBB11 is a potent heat shock factor 1 (HSF1) inhibitor, with an IC50 value of 1.2µM. KRIBB11 Chemical Structure
  64. GC31118 KU-32 KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death. KU-32 Chemical Structure
  65. GC14636 KW-2478

    KW2478,KW 2478

     An Hsp90 inhibitor KW-2478 Chemical Structure
  66. GC15042 Macbecin I

    (+)-Macbecin, NSC 330499

     Macbecin I is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin I exhibits antitumor and cytocidal activities. Macbecin I Chemical Structure
  67. GC69426 MAL3-101

    MAL3-101 is an effective inhibitor of heat shock protein 70 (HSP70) conformational changes. MAL3-101 inhibits HSP70 ATPase activity by blocking the interaction of Hsp40 molecular chaperones. MAL3-101 can be used for research on invasive bladder cancer.

     MAL3-101 Chemical Structure
  68. GC12301 Mizoribine

    NSC 289637

     DNA/RNA synthesis inhibitor Mizoribine Chemical Structure
  69. GC17751 MKT 077

    FJ-776

     mortalin-2 (mot-2) inhibitor MKT 077 Chemical Structure
  70. GC18170 ML-346 ML-346 is an activator of the heat shock response that induces the expression of the heat shock protein HSP70, with an EC50 value of 4.6µM. ML-346 Chemical Structure
  71. GC14322 MPC-3100 An inhibitor of Hsp90 MPC-3100 Chemical Structure
  72. GC64714 NCT-58 NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells. NCT-58 Chemical Structure
  73. GC45926 Nelfinavir-d3 An internal standard for the quantification of nelfinavir Nelfinavir-d3 Chemical Structure
  74. GC13105 NMS-E973 Hsp90 inhibitor,potent and selective NMS-E973 Chemical Structure
  75. GC11179 NVP-BEP800

    NVP-BEP800

     An Hsp90 inhibitor NVP-BEP800 Chemical Structure
  76. GC64655 NXP800

    CCT361814

     NXP800 (CCT361814) is a potent heat shock factor 1 (HSF1) inhibitor. NXP800 has?the?potential?for?cancer research. NXP800 Chemical Structure
  77. GC36834 p5 Ligand for Dnak and DnaJ p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ Chemical Structure
  78. GC71863 Palmitic acid-13C16 sodium Palmitic acid-13C16 (sodium) is the 13C-labeled Palmitic acid sodium. Palmitic acid-13C16 sodium Chemical Structure
  79. GC71865 Palmitic acid-13C2 Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid-13C2 Chemical Structure
  80. GC63852 Palmitic acid-d3 Palmitic acid-d3 Chemical Structure
  81. GC67916 Palmitic acid-d4 Palmitic acid-d4 Chemical Structure
  82. GC11912 PF-04929113 (SNX-5422)

    SNX-5422

    Hsp90 inhibitor,potent and selective

     PF-04929113 (SNX-5422) Chemical Structure
  83. GC69777 PU-H54

    PU-H54 is a selective inhibitor of Grp94, which can be used for the study of breast cancer. The Hsp90 chaperone family includes Hsp90α, Hsp90β, Grp94 and Trap-1, which play important roles in malignant tumors.

     PU-H54 Chemical Structure
  84. GC15143 PU-H71

    PU-H 71; PU H71

     Hsp90 inhibitor,potent and selective PU-H71 Chemical Structure
  85. GC37040 PU-H71 hydrochloride PU-H71 hydrochloride Chemical Structure
  86. GC13307 PU-WS13 PU-WS13 is a purine scaffold-based Grp94-specific heat shock protein 90 (Hsp90) inhibitor. PU-WS13 Chemical Structure
  87. GC11403 Radicicol

    KF9A, KF58332, Monorden, NSC 294404

     An inhibitor of Hsp90 Radicicol Chemical Structure
  88. GC10327 Retaspimycin Retaspimycin Chemical Structure
  89. GC19548 Rocaglamide

    Rocaglamide A; Roc-A

    Rocaglamide is a potent NF-κB activation inhibitor.

     Rocaglamide Chemical Structure
  90. GC33426 Rocaglamide (Rocaglamide A)

    Rocaglamide A; Roc-A

    Rocaglamide (Rocaglamide A) is isolated from the genus Aglaia (family Meliaceae). 

     Rocaglamide (Rocaglamide A) Chemical Structure
  91. GC71198 SEW84 SEW84 is an inhibitor of the Aha1stimulated Hsp90 (ASH) ATPase activity. SEW84 Chemical Structure
  92. GC64685 SNX-0723 SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 Chemical Structure
  93. GC13946 SNX-2112

    PF-04928473

     SNX-2112 is a potent inhibitor of synthetic heat shock protein (Hsp 90) with an IC50 value of 30nM. SNX-2112 Chemical Structure
  94. GC33047 SNX-5422 Mesylate (PF-04929113 (Mesylate)) SNX-5422 Mesylate (PF-04929113 (Mesylate)) Chemical Structure
  95. GC19521 Sodium Palmitate

    Hexadecanoic acid sodium salt, Palmitic acid sodium salt

    Sodium palmitate is a common saturated fatty acid produced during the process of fatty acid synthesis. Sodium Palmitate Chemical Structure
  96. GC17901 Tamoxifen Tamoxifen(TAM) serves as a selective estrogen receptor regulator (SERM), inhibiting estrogen's effects in breast cells while potentially stimulating estrogen activity in cells found in different tissues. Tamoxifen Chemical Structure
  97. GC11669 Tamoxifen Citrate

    ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide

     Antiestrogen drug Tamoxifen Citrate Chemical Structure
  98. GC48124 Tamoxifen-d5

    ICI 47699-?d5; (Z)-Tamoxifen-?d5; trans-Tamoxifen-?d5

     An internal standard for the quantification of tamoxifen Tamoxifen-d5 Chemical Structure
  99. GC33286 TAS-116

    TAS-116

     TAS-116 (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity. TAS-116 Chemical Structure
  100. GC33663 Teprenone (Geranylgeranylacetone)

    Teprenone

     Teprenone (Geranylgeranylacetone) is an anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs). Teprenone (Geranylgeranylacetone) Chemical Structure
  101. GC10481 TRC 051384 HSP70 inducer TRC 051384 Chemical Structure

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