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Home >> Signaling Pathways >> Metabolism >> HSP

HSP

Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.

Products for  HSP

  1. Cat.No. Product Name Information
  2. GC63796 116-9e

    MAL2-11B

     116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e Chemical Structure
  3. GC41955 17-DMAG

    Alvespimycin, KOS1022, NSC 707545

     17-DMAG (17-DMAG) is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. 17-DMAG Chemical Structure
  4. GC13044 17-DMAG (Alvespimycin) HCl 17-DMAG (Alvespimycin) HCl is an effective inhibitor of Hsp90, with an IC50 value of 62nM. 17-DMAG (Alvespimycin) HCl Chemical Structure
  5. GC65035 Apatorsen

    OGX-427

    Apatorsen?is?an?antisense?oligonucleotide?designed?to?bind?to?Hsp27?mRNA,?resulting?in?the?inhibition of?the?production?of?Hsp27?protein.

     Apatorsen Chemical Structure
  6. GC14411 Apoptozole

    Apoptosis Activator VII

     Apoptozole is a small inhibitor targets HSC70 and HSP72, with the KD values of 210nM and 140nM, respectively. Apoptozole Chemical Structure
  7. GC31103 Arimoclomol maleate (BRX-220)

    BRX-220

     Arimoclomol maleate (BRX-220) (BRX-220) is a co-inducer of heat shock proteins (HSP). Arimoclomol maleate (BRX-220) Chemical Structure
  8. GC68703 AT-533

    AT-533 is an effective inhibitor of Hsp90 and HSV. It inhibits tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits downstream pathway activation, including Akt/mTOR/p70S6K, Erk1/2, and FAK. AT-533 suppresses tube formation, cell migration, and invasion in human umbilical vein endothelial cells (HUVEC).

     AT-533 Chemical Structure
  9. GC13414 AT13387

    AT-13387,Onalespib

     AT13387 is a small-molecule, non-ansamycin HSP90 (heat shock protein 90) inhibitor that acts by targeting the AKT and ERK signaling pathways. AT13387 Chemical Structure
  10. GC72078 Azadiradione Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione Chemical Structure
  11. GC32620 Bimoclomol Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases. Bimoclomol Chemical Structure
  12. GC65318 BOLD-100

    NKP-1339 free base; IT-139 free base; KP-1339 free base

     BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 Chemical Structure
  13. GC10223 CCT018159 inhibitor of the ATPase activity of Hsp90 CCT018159 Chemical Structure
  14. GC19094 CCT251236 CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. CCT251236 Chemical Structure
  15. GC17822 CH5138303 Hsp90 inhibitor, orally available CH5138303 Chemical Structure
  16. GC34539 Col003

    Col003 is a selective and potent inhibitor of?Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM).

     Col003 Chemical Structure
  17. GC35757 Cucurbitacin D

    (+)-Cucurbitacin D, Elatericin A, NSC 308606, NSC 521776

     Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity. Cucurbitacin D Chemical Structure
  18. GC19121 Debio 0932

    CUDC-305

     Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively. Debio 0932 Chemical Structure
  19. GC38223 Dihydroberberine Dihydroberberine is a potent haematopoietic prostaglandin D2 synthase (H-PGDS), with an IC50 value of 3.7µM. Dihydroberberine Chemical Structure
  20. GC32965 Ethoxyquin

    NSC 6795

     An antioxidant used in animal feed Ethoxyquin Chemical Structure
  21. GC43649 Falcarinol Falcarinol is a naturally derived, orally active Hsp90 inhibitor. Falcarinol Chemical Structure
  22. GC32008 Feretoside Feretoside, a phenolic compound extracted from the barks of E. Feretoside Chemical Structure
  23. GC33030 Gamitrinib TPP Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial-targeted HSP90 inhibitor with anticancer activity used to chemically interfere with mitochondrial protein folding and induce mitophagy. Gamitrinib TPP Chemical Structure
  24. GC64795 Geldanamycin-FITC Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC Chemical Structure
  25. GC73388 GRP78-IN-3 GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 Chemical Structure
  26. GC64988 Grp94 Inhibitor-1 Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α. Grp94 Inhibitor-1 Chemical Structure
  27. GC19188 HA15 HA15 is a molecule that specifically targets BiP/GRP78/HSPA5, binding to and inhibiting its ATPase activity, which leads to the dissociation of BiP from PERK, IRE1α, and ATF6, thereby triggering endoplasmic reticulum stress. HA15 Chemical Structure
  28. GC72637 Hexadecanoate-13C16 potassium Hexadecanoate-13C16 (potassium) is the 13C-labeled Hexadecanoate sodium. Hexadecanoate-13C16 potassium Chemical Structure
  29. GC32437 HSF1A HSF1A is an activator of Heat Shock Transcription Factor 1 (HSF1). HSF1A Chemical Structure
  30. GC38503 HSP27 inhibitor J2

    J2

     HSP27 inhibitor J2 (J2) is an inhibitor of HSP27, which significantly induces abnormal HSP27 dimer formation and inhibits HSP27 macropolymer production. HSP27 inhibitor J2 Chemical Structure
  31. GC32869 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. HSP70-IN-1 Chemical Structure
  32. GC68450 Hsp90-IN-17 hydrochloride Hsp90-IN-17 hydrochloride Chemical Structure
  33. GC73701 HSP90-IN-27 HSP90-IN-27 (compound 19) is an HSP90 inhibitor. HSP90-IN-27 Chemical Structure
  34. GC11973 HSP990 (NVP-HSP990)

    NVP-HSP990

     HSP990 (NVP-HSP990) is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. HSP990 (NVP-HSP990) Chemical Structure
  35. GC73962 iHSP110-33

    iHSP110-33 is an inhibitor for heat shock protein 110 (HSP110).

     iHSP110-33 Chemical Structure
  36. GC69312 JG-231

    JG-231 is a JG-98 analogue with anti-cancer properties. It can inhibit the interaction between Hsp70-BAG3. JG-231 has an inhibitory effect on the MDA-MB-231 xenograft model of triple-negative breast cancer (TNBC).

     JG-231 Chemical Structure
  37. GC34634 JG-98 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. JG-98 Chemical Structure
  38. GC11930 KNK437

    Hsp Inhibitor I, KNK 437

     stress-induced HSP synthesis inhibitor KNK437 Chemical Structure
  39. GC64370 Kongensin A Kongensin A is a natural product isolated from Croton kongensis. Kongensin A Chemical Structure
  40. GC19215 KRIBB11 KRIBB11 is a potent heat shock factor 1 (HSF1) inhibitor, with an IC50 value of 1.2µM. KRIBB11 Chemical Structure
  41. GC31118 KU-32 KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death. KU-32 Chemical Structure
  42. GC69426 MAL3-101

    MAL3-101 is an effective inhibitor of heat shock protein 70 (HSP70) conformational changes. MAL3-101 inhibits HSP70 ATPase activity by blocking the interaction of Hsp40 molecular chaperones. MAL3-101 can be used for research on invasive bladder cancer.

     MAL3-101 Chemical Structure
  43. GC12301 Mizoribine

    NSC 289637

     DNA/RNA synthesis inhibitor Mizoribine Chemical Structure
  44. GC17751 MKT 077

    FJ-776

     mortalin-2 (mot-2) inhibitor MKT 077 Chemical Structure
  45. GC64714 NCT-58 NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells. NCT-58 Chemical Structure
  46. GC13105 NMS-E973 Hsp90 inhibitor,potent and selective NMS-E973 Chemical Structure
  47. GC64655 NXP800

    CCT361814

     NXP800 (CCT361814) is a potent heat shock factor 1 (HSF1) inhibitor. NXP800 has?the?potential?for?cancer research. NXP800 Chemical Structure
  48. GC36834 p5 Ligand for Dnak and DnaJ p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ Chemical Structure
  49. GC71863 Palmitic acid-13C16 sodium Palmitic acid-13C16 (sodium) is the 13C-labeled Palmitic acid sodium. Palmitic acid-13C16 sodium Chemical Structure
  50. GC71865 Palmitic acid-13C2 Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid-13C2 Chemical Structure
  51. GC63852 Palmitic acid-d3 Palmitic acid-d3 Chemical Structure
  52. GC67916 Palmitic acid-d4 Palmitic acid-d4 Chemical Structure
  53. GC11912 PF-04929113 (SNX-5422)

    SNX-5422

    Hsp90 inhibitor,potent and selective

     PF-04929113 (SNX-5422) Chemical Structure
  54. GC69777 PU-H54

    PU-H54 is a selective inhibitor of Grp94, which can be used for the study of breast cancer. The Hsp90 chaperone family includes Hsp90α, Hsp90β, Grp94 and Trap-1, which play important roles in malignant tumors.

     PU-H54 Chemical Structure
  55. GC37040 PU-H71 hydrochloride PU-H71 hydrochloride Chemical Structure
  56. GC13307 PU-WS13 PU-WS13 is a purine scaffold-based Grp94-specific heat shock protein 90 (Hsp90) inhibitor. PU-WS13 Chemical Structure
  57. GC19548 Rocaglamide

    Rocaglamide A; Roc-A

    Rocaglamide is a potent NF-κB activation inhibitor.

     Rocaglamide Chemical Structure
  58. GC71198 SEW84 SEW84 is an inhibitor of the Aha1stimulated Hsp90 (ASH) ATPase activity. SEW84 Chemical Structure
  59. GC64685 SNX-0723 SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 Chemical Structure
  60. GC33047 SNX-5422 Mesylate (PF-04929113 (Mesylate)) SNX-5422 Mesylate (PF-04929113 (Mesylate)) Chemical Structure
  61. GC19521 Sodium Palmitate

    Hexadecanoic acid sodium salt, Palmitic acid sodium salt

    Sodium palmitate is a common saturated fatty acid produced during the process of fatty acid synthesis. Sodium Palmitate Chemical Structure
  62. GC17901 Tamoxifen Tamoxifen(TAM) serves as a selective estrogen receptor regulator (SERM), inhibiting estrogen's effects in breast cells while potentially stimulating estrogen activity in cells found in different tissues. Tamoxifen Chemical Structure
  63. GC11669 Tamoxifen Citrate

    ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide

     Antiestrogen drug Tamoxifen Citrate Chemical Structure
  64. GC33286 TAS-116

    TAS-116

     TAS-116 (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity. TAS-116 Chemical Structure
  65. GC33663 Teprenone (Geranylgeranylacetone)

    Teprenone

     Teprenone (Geranylgeranylacetone) is an anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs). Teprenone (Geranylgeranylacetone) Chemical Structure
  66. GC10481 TRC 051384 HSP70 inducer TRC 051384 Chemical Structure
  67. GC13556 VER-49009

    CCT 129397

     HSP90 inhibitor, potent and selective VER-49009 Chemical Structure
  68. GC10501 VER-50589 HSP90 inhibitor, potent VER-50589 Chemical Structure
  69. GC66059 YZ129 YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration. YZ129 Chemical Structure
  70. GC72823 Zelavespib formic

    PU-H71 formic

     Zelavespib formic (PU-H71 formic) is a potent Hsp90 inhibitor with an IC50 value of 51 nM for Hsp90 in MDA-MB-468 cells. Zelavespib formic Chemical Structure
  71. GC72822 Zelavespib hydrochloride

    PU-H71 hydrochloride

     Zelavespib (PU-H71) drochloride is a potent Hsp90 inhibitor, with an IC50 of 51 nM in MDA-MB-468 cells. Zelavespib hydrochloride Chemical Structure

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