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HSP

Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.

Products for  HSP

  1. Cat.No. Product Name Information
  2. GC63796 116-9e 116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e  Chemical Structure
  3. GC41955 17-DMAG 17-DMAG (17-DMAG) is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. 17-DMAG  Chemical Structure
  4. GC13044 17-DMAG (Alvespimycin) HCl 17-DMAG (Alvespimycin) HCl (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM. 17-DMAG (Alvespimycin) HCl  Chemical Structure
  5. GC65035 Apatorsen Apatorsen?is?an?antisense?oligonucleotide?designed?to?bind?to?Hsp27?mRNA,?resulting?in?the?inhibition of?the?production?of?Hsp27?protein. Apatorsen  Chemical Structure
  6. GC14411 Apoptozole inhibitor of heat shock protein 70 (Hsp70) Apoptozole  Chemical Structure
  7. GC31103 Arimoclomol maleate (BRX-220) Arimoclomol maleate (BRX-220) (BRX-220) is a co-inducer of heat shock proteins (HSP). Arimoclomol maleate (BRX-220)  Chemical Structure
  8. GC13414 AT13387 AT13387 (AT13387) is a long-acting second-generation Hsp90 inhibitor with a Kd of 0.71 nM. AT13387  Chemical Structure
  9. GC32620 Bimoclomol Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases. Bimoclomol  Chemical Structure
  10. GC65318 BOLD-100 BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution. BOLD-100  Chemical Structure
  11. GC10223 CCT018159 inhibitor of the ATPase activity of Hsp90 CCT018159  Chemical Structure
  12. GC19094 CCT251236 CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. CCT251236  Chemical Structure
  13. GC17822 CH5138303 Hsp90 inhibitor, orally available CH5138303  Chemical Structure
  14. GC34539 Col003

    Col003 is a selective and potent inhibitor of?Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM).

    Col003  Chemical Structure
  15. GC35757 Cucurbitacin D Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity. Cucurbitacin D  Chemical Structure
  16. GC19121 Debio 0932 Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively. Debio 0932  Chemical Structure
  17. GC38223 Dihydroberberine Dihydroberberine  Chemical Structure
  18. GC32965 Ethoxyquin An antioxidant used in animal feed Ethoxyquin  Chemical Structure
  19. GC43649 Falcarinol

    Falcarinol is a C17-polyacetylene produced by the Apiaceae family that has antimicrobial properties due to its inhibition of fatty acid biosynthesis.

    Falcarinol  Chemical Structure
  20. GC32008 Feretoside Feretoside, a phenolic compound extracted from the barks of E. Feretoside  Chemical Structure
  21. GC64795 Geldanamycin-FITC Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC  Chemical Structure
  22. GC64988 Grp94 Inhibitor-1 Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α. Grp94 Inhibitor-1  Chemical Structure
  23. GC19188 HA15 HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15  Chemical Structure
  24. GC32437 HSF1A HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1). HSF1A  Chemical Structure
  25. GC38503 HSP27 inhibitor J2

    HSP27 inhibitor J2 (J2) is an inhibitor of HSP27, which significantly induces abnormal HSP27 dimer formation and inhibits HSP27 macropolymer production[1-3].

    HSP27 inhibitor J2  Chemical Structure
  26. GC32869 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. HSP70-IN-1  Chemical Structure
  27. GC68450 Hsp90-IN-17 hydrochloride Hsp90-IN-17 hydrochloride  Chemical Structure
  28. GC11973 HSP990 (NVP-HSP990) HSP990 (NVP-HSP990) is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. HSP990 (NVP-HSP990)  Chemical Structure
  29. GC34634 JG-98 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. JG-98  Chemical Structure
  30. GC11930 KNK437 stress-induced HSP synthesis inhibitor KNK437  Chemical Structure
  31. GC64370 Kongensin A Kongensin A is a natural product isolated from Croton kongensis. Kongensin A  Chemical Structure
  32. GC19215 KRIBB11 KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 uM. KRIBB11  Chemical Structure
  33. GC31118 KU-32 KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death. KU-32  Chemical Structure
  34. GC12301 Mizoribine DNA/RNA synthesis inhibitor Mizoribine  Chemical Structure
  35. GC17751 MKT 077 mortalin-2 (mot-2) inhibitor MKT 077  Chemical Structure
  36. GC64714 NCT-58 NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells. NCT-58  Chemical Structure
  37. GC13105 NMS-E973 Hsp90 inhibitor,potent and selective NMS-E973  Chemical Structure
  38. GC64655 NXP800 NXP800 (CCT361814) is a potent heat shock factor 1 (HSF1) inhibitor. NXP800 has?the?potential?for?cancer research. NXP800  Chemical Structure
  39. GC36834 p5 Ligand for Dnak and DnaJ p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ  Chemical Structure
  40. GC63852 Palmitic acid-d3 Palmitic acid-d3  Chemical Structure
  41. GC67916 Palmitic acid-d4 Palmitic acid-d4  Chemical Structure
  42. GC11912 PF-04929113 (SNX-5422)

    Hsp90 inhibitor,potent and selective

    PF-04929113 (SNX-5422)  Chemical Structure
  43. GC69777 PU-H54

    PU-H54 is a selective inhibitor of Grp94, which can be used for the study of breast cancer. The Hsp90 chaperone family includes Hsp90α, Hsp90β, Grp94 and Trap-1, which play important roles in malignant tumors.

    PU-H54  Chemical Structure
  44. GC37040 PU-H71 hydrochloride PU-H71 hydrochloride  Chemical Structure
  45. GC13307 PU-WS13

    Grp94-specific Hsp90 inhibitor

    PU-WS13  Chemical Structure
  46. GC19548 Rocaglamide

    Rocaglamide is a potent NF-κB activation inhibitor.

    Rocaglamide  Chemical Structure
  47. GC64685 SNX-0723 SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723  Chemical Structure
  48. GC33047 SNX-5422 Mesylate (PF-04929113 (Mesylate)) SNX-5422 Mesylate (PF-04929113 (Mesylate))  Chemical Structure
  49. GC17901 Tamoxifen Tamoxifen(TAM) serves as a selective estrogen receptor regulator (SERM), inhibiting estrogen's effects in breast cells while potentially stimulating estrogen activity in cells found in different tissues. Tamoxifen  Chemical Structure
  50. GC11669 Tamoxifen Citrate Antiestrogen drug Tamoxifen Citrate  Chemical Structure
  51. GC33286 TAS-116 TAS-116 (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity. TAS-116  Chemical Structure
  52. GC33663 Teprenone (Geranylgeranylacetone) Teprenone (Geranylgeranylacetone) is an anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs). Teprenone (Geranylgeranylacetone)  Chemical Structure
  53. GC10481 TRC 051384 HSP70 inducer TRC 051384  Chemical Structure
  54. GC13556 VER-49009 HSP90 inhibitor, potent and selective VER-49009  Chemical Structure
  55. GC10501 VER-50589 HSP90 inhibitor, potent VER-50589  Chemical Structure
  56. GC66059 YZ129 YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration. YZ129  Chemical Structure

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