GLPBio

Compstatin

Catalog No.: GC15251Purity:>98%
COASDSData Sheet
Complement inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

Compstatin
Cas No.: 206645-99-0
1mgIn Stock
$81.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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Description

Compstatin is a 13-residue cyclic peptide and a potent inhibitor of the complement system, and has species specificity.

Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans); Compstatin inhibits only the activation of primates' complement system[1].

Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures[1]. Pig xenografts survival is significantlylonger in the Compstatin perfused group than in the control group. At rejection the biopsy samples obtained from kidneysperfused with Compstatin show less deposition of C3 and fibrin than do the control kidneys[2].

References:
[1]. Soulika AM, et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol. 2000 Sep;96(3):212-21.
[2]. Fiane AE, et al. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation. 1999 Feb;6(1):52-65.

Protocol

Animal experiment:

Compstatin-perfused circuit: pig xenografts are perfused with human blood containing Compstatin (final conc. 0.088 mg/mL). Control group: pig kidneys perfused with human blood and control agent. The total fluid volume, protein concentration and amount of blood are equal in both the Compstatin and control perfusion circuits, and the perfusion is performed in both circuits simultaneously with pooled blood from the same two donors.

References:

[1]. Soulika AM, et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol. 2000 Sep;96(3):212-21.
[2]. Fiane AE, et al. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation. 1999 Feb;6(1):52-65.

Chemical Properties

CAS No.
206645-99-0
Chemical Name
2-((4R,5Z,7S,8Z,10S,11Z,13S,14Z,17Z,19S,20Z,22S,23Z,25S,26Z,28S,29Z,31S,32Z,34R)-10,13-bis((1H-imidazol-5-yl)methyl)-19-((1H-indol-3-yl)methyl)-34-((Z)-((2S,3S)-2-amino-1-hydroxy-3-methylpentylidene)amino)-4-((Z)-(((2S,3R)-1,3-dihydroxy-1-iminobutan-2-yl)
SMILES
CC[C@]([C@@](N)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/1)([H])CCCNC(N)=N)([H])CC2=CN=CN2)([H])CC3=CN=CN3)([H])CC4=CNC5=CC=CC=C45)([H])CC(O)=O)([H])
Molecular Formula
C66H99N23O17S2
Molecular Weight
1550.77
Solubility
Soluble to 2 mg/ml in sterile water
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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