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CRFR

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CRFR (Corticotropin-releasing Factor Receptor), also known as corticotropin-releasing hormone receptor (CRHR), belongs to the G protein-coupled receptor family. There are 3 types of this recetpor, CRF1, CRF2 and CRF3 receptor. CRF1 receptor (CRF1 or CRF1α) is functionally coupled to adenylate cyclase and it belongs to the secretin-like, family B of GPCRs. CRF1 receptor has several splice variants (CRF1c-CRF1m) including CRF1β. CRF2 receptor is a 411-amino acid protein with approximately 70% identity to the known CRF1 and it is functionally coupled to adenylate cyclase. The CRF2 receptor has been shown to be expressed as three functional splice variants, the CRF2α (411-413 amino acids), the CRF2β (431-438 amino acids) and the CRF2γ (397 amino acids). CRF3 receptor is a 428-amino acid protein, which binds CRF with a 5-fold higher affinity than URO and SVG and is expressed in the pituitary gland, urophysis, and brain.

CRFR subserves central functions related to stress physiology, and also exerts peripheral actions relevant to cardiovascular, muscular, gastrointestinal, pancreatic, inflammatory, and neoplastic diseases.

Products Related to CRFR(27)

  • GC12802 structure
    GC12802Urocortin (rat)
    CAS: 171543-83-2
    Purity: >98%

    Endogenous CRF agonist

  • GC17432 structure
    GC17432Urocortin (human)
    CAS: 176591-49-4
    Purity: >98.00%

    Endogenous CRF agonist

  • GC19374 structure
    GC19374Verucerfont
    CAS: 885220-61-1
    Purity: >99.00%

    Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.

  • GC30792 structure
    GC30792R121919 (NBI30775)
    CAS: 195055-03-9
    Purity: >98.00%

    R121919 (NBI30775) (NBI30775) is a potent small-molecule CRF1 receptor antagonist with a Ki of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.

  • GC30863 structure
    GC30863CP 376395 (CP-316311)
    CAS: 175140-00-8
    Purity: >99.50%

    CP 376395 (CP-316311) is a potent and selective Corticotropin releasing factor 1 (CRF1) receptor antagonist.

  • GC31030 structure
    GC31030DMP 696
    CAS: 202578-52-7
    Purity: >99.00%

    DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist.

  • GC31043 structure
    GC31043CP 316311
    CAS: 175139-41-0
    Purity: >98%

    CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.

  • GC31166 structure
    GC31166Emicerfont (GW876008)
    CAS: 786701-13-1
    Purity: >98%

    Emicerfont (GW876008) is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.

  • GC32590 structure
    GC32590Urotensin I (Catostomus urotensin I)
    CAS: 83930-33-0
    Purity: >98%

    Urotensin I (Catostomus urotensin I) (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.

  • GC33712 structure
    GC33712Pexacerfont (BMS-562086)
    CAS: 459856-18-9
    Purity: >99.50%

    Pexacerfont (BMS-562086) is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor.

  • GC34542 structure
    GC34542CRF, bovine TFA
    Purity: >98%

    CRF, bovine (TFA) is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.

  • GC35748 structure
    GC35748CRF, bovine
    CAS: 92307-52-3
    Purity: >98.00%

    CRF, bovine is an important neuropeptide consisting of 41 amino acids, it is produced by the hypothalamus and is transported to the pituitary, where it triggers the release of adrenocorticotropic hormone (ACTH).

  • GC36787 structure
    GC36787NVS-CRF38
    CAS: 1207258-55-6
    Purity: >98%

    NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.

  • GC37868 structure
    GC37868Urocortin II, human
    CAS: 351999-18-3
    Purity: >99.5%

    Urocortin II (human) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor.

  • GC37869 structure
    GC37869Urocortin III, mouse
    CAS: 357952-10-4
    Purity: >98%

    Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide.

  • GC37870 structure
    GC37870Urocortin III, mouse (TFA)
    Purity: >99.50%
  • GC38886 structure
    GC38886Antisauvagine-30 TFA
    Purity: >98.00%

    Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist.

  • GC50455 structure
    GC50455Cortagine
    Purity: >98%

    Cortagine is a kind of corticotropin-releasing factor receptor subtype 1 (CRF1) peptidic agonist, with an IC 50 of 2.6nM and an EC 50 of 0.47nM for rCRF1.

  • GC60724 structure
    GC60724Corticotropin-releasing factor (human) (acetate)
    Purity: >98.50%

    Corticotropin-releasing factor human acetate (Human CRF acetate) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.

  • GC61583 structure
    GC61583Urotensin I TFA
    Purity: >98.00%

    Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.

  • GC65893 structure
    GC65893Tildacerfont
    CAS: 1014983-00-6
    Purity: >98%

    Tildacerfont is a potent and orally active corticotrophin-releasing factor type 1 (CRF1) receptort antagonis. Tildacerfont effectively reduces adrenocorticotropic hormone (ACTH) and adrenal androgen levels. Tildacerfont has favourable safety profile. Tildacerfont can be used for researching congenital adrenal hyperplasia.

  • GC66088 structure
    GC66088α-Helical CRF(9-41) TFA
    Purity: >99.00%

    α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM.

  • GC70559 structure
    GC70559Antalarmin
    CAS: 157284-96-3
    Purity: >97.00%

    Antalarmin, a pyrrolopyrimidine, is a potent, small molecule, nonpeptide CRF1 (Corticotropin-Releasing Factor Receptor 1) selective receptor antagonist.

  • GC72120 structure
    GC72120Stressin I TFA
    Purity: >98.00%

    Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist, Ki is 1.7 nM.