CU-CPT-9a |
| Catalog No.GC31745 |
A TLR8 antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2165340-32-7
Sample solution is provided at 25 µL, 10mM.
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CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.
CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases[1].
[1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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