TLR
TLR (Toll-like receptor) is a family of receptors that expressed on immune cells including B lymphoctes, macrophages and mast cells. Ir identifies pathogen-associated molecular patterns and mediate the cytokines productions for activation of innate immunity.
Products for TLR
- Cat.No. Product Name Information
- GC66870 β-D-Glucan β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery. β-d-glucan is an enteric delivery vehicle for probiotics.
- GC38728 1V209 1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity.
- GC63485 Afimetoran Afimetoran is a toll-like receptor antagonist, which can be used in the research of inflammatory and autoimmune diseases.
- GC66396 Agatolimod Agatolimod (ODN 2006), a class B ODN (oligodeoxynucleotide), is a TLR9 agonist. Agatolimod is also an optimal CpG sequence for humans. Agatolimod stimulates very strong production of NO2 and IL-6 in HD11 cells. Agatolimod can be used for breast cancer research. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'.
- GC32057 AN-3485 AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.
- GC62334 AT791 AT791 is a potent and orally bioavailable TLR7 and TLR9 inhibitor.
- GN10627 Atractylenolide I
- GC65283 AXC-715 trihydrochloride AXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1.
- GC62488 AZD8848 AZD8848 is a selective toll-like receptor 7 (TLR7) antedrug agonist which is developed for the research of asthma and allergic rhinitis.
- GC16345 Bropirimine Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract.
- GC33820 C29 C29 is a Toll-like receptor 2 (TLR2) inhibitor.
- GC60694 Chitohexaose hexahydrochloride Chitohexaose hexahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect.
- GC60700 Chloroquine D5 Chloroquine D5 is deuterium labeled Chloroquine.
- GC10295 Chloroquine diphosphate Chloroquine diphosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis.
- GC50356 CL 075 TLR8 agonist
- GC64526 CL097 CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages.
- GC65124 CL097 hydrochloride CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages.
- GC14254 CU CPT 22 toll-like receptor 1/2 (TLR1/2) inhibitor
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GC11461
CU CPT 4a
TLR3 inhibitor
- GC47127 CU-115 A TLR8 antagonist
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GC25314
CU-CPD107
CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands.
- GC31745 CU-CPT-9a A TLR8 antagonist
- GC31729 CU-CPT-9b (TLR8-specific antagonist 1) CU-CPT-9b (TLR8-specific antagonist 1) is a specific TLR8 antagonist, with an IC50 of 0.7 nM.
- GC33834 CU-CPT17e CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist that activates TLR3, TLR8, and TLR9.
- GC18306 CU-CPT8m CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8; Kd = 220 nM; IC50 = 67 nM in a reporter assay).
- GC39285 CU-T12-9 An agonist of TLR1/2
- GC68432 DB-3-291
- GC39372 Desethyl chloroquine diphosphate Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine.
- GC47194 Desethylchloroquine An active metabolite of chloroquine
- GC38907 DSR-6434 DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect.
- GC33900 E6446
- GC33828 E6446 dihydrochloride (E-6446 dihydrochloride)
- GC62489 Enpatoran Enpatoran (M5049) is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively.
- GC62471 Enpatoran hydrochloride Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively.
- GC18761 FSL-1 FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6).
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GC60860
FSL-1 TFA
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
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GC14864
Gardiquimod
agonist of human toll-like receptor 7 (TLR7)
- GC33910 Gardiquimod trifluoroacetate Gardiquimod trifluoroacetate, an imidazoquinoline analog, is a TLR7/8 agonist.
- GC12555 GS-9620 A TLR7 agonist
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GC12544
Hydroxychloroquine Sulfate
Autophagy inhibitor
- GC65365 IAXO-102 IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling.
- GC10712 Imiquimod hydrochloride Toll-like receptor 7 agonist
- GC12645 Imiquimod maleate Immune response modifier
- GC39134 Isofraxidin Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells.
- GC64417 L48H37 L48H37 is an analog of Curcumin with improved chemical stability.
- GC66478 LHC-165 LHC-165 is a TLR7 agonist. LHC-165 has potential to used in study of solid tumors.
- GC65924 Lipopolysaccharides Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells. This product is derived from Escherichia coli O55:B5.
- GC50241 M62812 TLR-4 inhibitor
- GC31776 MD2-IN-1 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 ?μM for the recombinant human MD2 (rhMD2).
- GC36578 MD2-TLR4-IN-1 MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively.
- GC64953 MMG-11 MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity.
- GC11168 Motolimod (VTX-2337) Motolimod (VTX-2337) (VTX-2337;VTX-378) is a selective Toll-like receptor 8 (TLR8) agonist, with an EC50 of approximately 100 nM.
- GC33405 Neoseptin 3 Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC50 of 18.5 μM.
- GC66393 ODN 1018 ODN 1018 (1018 ISS), an oligodeoxynucleotide, is a TLR-9 agonist. ODN 1018 is also a synthetic immunostimulatory sequence that can be used as vaccine adjuvant. Sequence: 5′-TGACTGTGAACGTTCGAGATGA-3′.
- GC68294 ODN 1668
- GC65448 ODN 1826 ODN 1826, a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist.
- GC66341 ODN 2088 ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6.
- GC66339 ODN 2216 ODN 2216 is a TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4+ T cells.
- GC68292 ODN 2395
- GC36794 Okanin Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways.
- GC10058 Pam2CSK4 toll-like receptor 2/6 (TLR2/6) agonist
- GC13200 Pam2CSK4 Biotin biotinylated Pam2CSK4, a toll-like receptor 2/6 agonist
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GC10273
Pam3CSK4
Pam3CSK4 (Pam3CysSerLys4) is a synthetic triacylated lipopeptide (LP) and a TLR2/TLR1 ligand?agonist with an EC50 of 0.47 ng/mL.
- GC16445 Pam3CSK4 Biotin biotinylated Pam3CSK4, a toll-like receptor 1/2 agonist
- GC64486 Pepinh-TRIF TFA Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction.
- GC31792 PF-4878691 (3M-852A) PF-4878691 (3M-852A) (3M-852A) is a potent, orally active, and selective Toll-like receptor 7 (TLR7) agonist modelled to dissociate its antiviral and inflammatory activities.
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GC14710
Poly(I:C)
Poly (I:C), a synthetic double-stranded RNA (dsRNA) analog, is an immunostimulant that acts as the most potent interferon (IFN) inducer.
- GN10312 Polygalasaponin F
- GC13800 Polyinosinic-polycytidylic Acid (potassium salt) synthetic dsRNA that activates TLR3 and retinoic acid inducible gene 1 (RIG-1)-like receptors
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GC60297
Polyinosinic-polycytidylic acid sodium
Polyinosinic-polycytidylic acid sodium(Poly I:C) is a synthetic dsRNA that can imitate a viral infection and elicit host immune responses by triggering specific pattern-recognition receptors (PRRs).
- GN10348 Proanthocyanidin B1
- GC13650 Resiquimod (R-848) Resiquimod (R-848) is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.
- GC62636 Resiquimod-d5 Resiquimod-d5 (R848-d5) is deuterium labeled Resiquimod.
- GC60328 Robinin Robinin is present in?flavonoid?fraction of?Vigna unguiculata?leaf.
- GC50297 RS 09 TLR4 peptide agonist; acts as an adjuvant in vivo
- GC63760 RS 09 TFA RS 09 TFA is a TLR4 agonist.
- GC16538 RWJ 21757 RWJ 21757 (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities.
- GN10091 Schaftoside
- GC50165 SM 324405 Potent TLR7 agonist
- GC60344 Sparstolonin B Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling.
- GC64456 Stepharine Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor).
- GC61803 Sulfo-ara-F-NMN Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN).
- GC14438 Suprofen dual COX-1/COX-2 inhibitor
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GC16148
TAK-242
A TLR4 antagonist
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GC11294
TAK-242 S enantiomer
TLR 4 signaling inhibitor
- GC33076 Telratolimod (MEDI 9197) Telratolimod (MEDI 9197) (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.
- GC50374 TH 1020 Toll-like receptor (TLR) 5/Flagellin complex antagonist
- GC64901 TLR7 agonist 4 TLR7 agonist 4 (Compound 1.2) is a TLR7 agonist with an EC50 of 4.3 nM.
- GC19357 TLR7-agonist-1 TLR7-agonist-1 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM.
- GC30516 TLR7/8 agonist 1 dihydrochloride A dual agonist of TLR7 and TLR8
- GC62395 TLR7/8 agonist 3 TLR7/8 agonist 3 is a potent TLR7 and TLR8 agonist, extracted from patent WO2016057618 (compound of formula (II)).
- GC65915 TLR7/8 agonist 4 TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist. TLR7/8 agonist 4 has anti-cancer activity.
- GC62668 TLR7/8-IN-1 TLR7/8-IN-1 is a crystalline from of a TLR7/TLR8 inhibitor extracted from patent WO2019220390, compound 2b.
- GC67699 TLR8 agonist 5
- GC17996 Toll-like receptor modulator
- GC64262 Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34.