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Home >> Signaling Pathways >> Immunology/Inflammation >> TLR

TLR

TLR (Toll-like receptor) is a family of receptors that expressed on immune cells including B lymphoctes, macrophages and mast cells. Ir identifies pathogen-associated molecular patterns and mediate the cytokines productions for activation of innate immunity.

Products for  TLR

  1. Cat.No. Product Name Information
  2. GC66870 β-D-Glucan β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery. β-d-glucan is an enteric delivery vehicle for probiotics. β-D-Glucan Chemical Structure
  3. GC38728 1V209

    TLR7 agonist T7

     1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity. 1V209 Chemical Structure
  4. GC63485 Afimetoran

    BMS-986256

     Afimetoran is a toll-like receptor antagonist, which can be used in the research of inflammatory and autoimmune diseases. Afimetoran Chemical Structure
  5. GC66396 Agatolimod

    ODN 2006; CpG 7909; PF-3512676

     Agatolimod (ODN 2006), a class B ODN (oligodeoxynucleotide), is a TLR9 agonist. Agatolimod is also an optimal CpG sequence for humans. Agatolimod stimulates very strong production of NO2 and IL-6 in HD11 cells. Agatolimod can be used for breast cancer research. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'. Agatolimod Chemical Structure
  6. GC32057 AN-3485 AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM. AN-3485 Chemical Structure
  7. GC62334 AT791 AT791 is a potent and orally bioavailable TLR7 and TLR9 inhibitor. AT791 Chemical Structure
  8. GN10627 Atractylenolide I Atractylenolide I Chemical Structure
  9. GC65283 AXC-715 trihydrochloride

    T785 trihydrochloride

     AXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1. AXC-715 trihydrochloride Chemical Structure
  10. GC62488 AZD8848 AZD8848 is a selective toll-like receptor 7 (TLR7) antedrug agonist which is developed for the research of asthma and allergic rhinitis. AZD8848 Chemical Structure
  11. GC16345 Bropirimine

    ABPP, NSC 149027, PNU 54461, U-54461

     Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract. Bropirimine Chemical Structure
  12. GC33820 C29

    TLR2-IN-C29

     C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 Chemical Structure
  13. GC60694 Chitohexaose hexahydrochloride Chitohexaose hexahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect. Chitohexaose hexahydrochloride Chemical Structure
  14. GC60700 Chloroquine D5 Chloroquine D5 is deuterium labeled Chloroquine. Chloroquine D5 Chemical Structure
  15. GC10295 Chloroquine diphosphate

    DL-Chloroquine, NSC 14050

     Chloroquine diphosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine diphosphate Chemical Structure
  16. GC50356 CL 075 TLR8 agonist CL 075 Chemical Structure
  17. GC64526 CL097 CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages. CL097 Chemical Structure
  18. GC65124 CL097 hydrochloride CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages. CL097 hydrochloride Chemical Structure
  19. GC11461 CU CPT 4a

    TLR3-IN-1

    TLR3 inhibitor

     CU CPT 4a Chemical Structure
  20. GC47127 CU-115 A TLR8 antagonist CU-115 Chemical Structure
  21. GC25314 CU-CPD107

    CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands.

     CU-CPD107 Chemical Structure
  22. GC31745 CU-CPT-9a A TLR8 antagonist CU-CPT-9a Chemical Structure
  23. GC31729 CU-CPT-9b (TLR8-specific antagonist 1) CU-CPT-9b (TLR8-specific antagonist 1) is a specific TLR8 antagonist, with an IC50 of 0.7 nM. CU-CPT-9b (TLR8-specific antagonist 1) Chemical Structure
  24. GC33834 CU-CPT17e CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist that activates TLR3, TLR8, and TLR9. CU-CPT17e Chemical Structure
  25. GC14254 CU-CPT22 CU CPT 22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41µM. CU CPT 22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58µM. CU-CPT22 Chemical Structure
  26. GC18306 CU-CPT8m

    TLR8-specific antagonist

     CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8; Kd = 220 nM; IC50 = 67 nM in a reporter assay). CU-CPT8m Chemical Structure
  27. GC39285 CU-T12-9 An agonist of TLR1/2 CU-T12-9 Chemical Structure
  28. GC68432 DB-3-291 DB-3-291 Chemical Structure
  29. GC39372 Desethyl chloroquine diphosphate Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Desethyl chloroquine diphosphate Chemical Structure
  30. GC47194 Desethylchloroquine

    N-Desethylchloroquine, NSC 13254

     An active metabolite of chloroquine Desethylchloroquine Chemical Structure
  31. GC38907 DSR-6434 DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect. DSR-6434 Chemical Structure
  32. GC33900 E6446 E6446 Chemical Structure
  33. GC33828 E6446 dihydrochloride (E-6446 dihydrochloride) E6446 dihydrochloride (E-6446 dihydrochloride) Chemical Structure
  34. GC62489 Enpatoran

    M5049

     Enpatoran (M5049) is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran Chemical Structure
  35. GC62471 Enpatoran hydrochloride

    M5049 hydrochloride

     Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride Chemical Structure
  36. GC18761 FSL-1 FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6). FSL-1 Chemical Structure
  37. GC60860 FSL-1 TFA

    FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.

     FSL-1 TFA Chemical Structure
  38. GC14864 Gardiquimod

    agonist of human toll-like receptor 7 (TLR7)

     Gardiquimod Chemical Structure
  39. GC33910 Gardiquimod trifluoroacetate Gardiquimod trifluoroacetate, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod trifluoroacetate Chemical Structure
  40. GC12555 GS-9620

    Vesatolimod

     A TLR7 agonist GS-9620 Chemical Structure
  41. GC12544 Hydroxychloroquine Sulfate

    HCQ, NSC 4375

    Autophagy inhibitor

     Hydroxychloroquine Sulfate Chemical Structure
  42. GC65365 IAXO-102 IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 Chemical Structure
  43. GC16407 Imiquimod

    R-837, S-26308, TMX 101

    TLR-7 agonist,immunomodulator with antiviral and antitumor activity

     Imiquimod Chemical Structure
  44. GC10712 Imiquimod hydrochloride

    Toll-like receptor 7 agonist

     Imiquimod hydrochloride Chemical Structure
  45. GC12645 Imiquimod maleate Immune response modifier Imiquimod maleate Chemical Structure
  46. GC39134 Isofraxidin Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin Chemical Structure
  47. GC64417 L48H37 L48H37 is an analog of Curcumin with improved chemical stability. L48H37 Chemical Structure
  48. GC66478 LHC-165 LHC-165 is a TLR7 agonist. LHC-165 has potential to used in study of solid tumors. LHC-165 Chemical Structure
  49. GC65924 Lipopolysaccharides

    LPS

     Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells. This product is derived from Escherichia coli O55:B5. Lipopolysaccharides Chemical Structure
  50. GC50241 M62812 TLR-4 inhibitor M62812 Chemical Structure
  51. GC31776 MD2-IN-1 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 ?μM for the recombinant human MD2 (rhMD2). MD2-IN-1 Chemical Structure
  52. GC36578 MD2-TLR4-IN-1 MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 Chemical Structure
  53. GC64953 MMG-11 MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 Chemical Structure
  54. GC11168 Motolimod (VTX-2337)

    VTX-2337

     Motolimod (VTX-2337) (VTX-2337;VTX-378) is a selective Toll-like receptor 8 (TLR8) agonist, with an EC50 of approximately 100 nM. Motolimod (VTX-2337) Chemical Structure
  55. GC33405 Neoseptin 3 Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC50 of 18.5 μM. Neoseptin 3 Chemical Structure
  56. GC66393 ODN 1018

    1018 ISS

     ODN 1018 (1018 ISS), an oligodeoxynucleotide, is a TLR-9 agonist. ODN 1018 is also a synthetic immunostimulatory sequence that can be used as vaccine adjuvant. Sequence: 5′-TGACTGTGAACGTTCGAGATGA-3′. ODN 1018 Chemical Structure
  57. GC68294 ODN 1668 ODN 1668 Chemical Structure
  58. GC65448 ODN 1826

    CpG 1826

     ODN 1826, a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 Chemical Structure
  59. GC66341 ODN 2088 ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6. ODN 2088 Chemical Structure
  60. GC66339 ODN 2216 ODN 2216 is a TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4+ T cells. ODN 2216 Chemical Structure
  61. GC68292 ODN 2395 ODN 2395 Chemical Structure
  62. GC36794 Okanin Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Okanin Chemical Structure
  63. GC10058 Pam2CSK4 toll-like receptor 2/6 (TLR2/6) agonist Pam2CSK4 Chemical Structure
  64. GC13200 Pam2CSK4 Biotin biotinylated Pam2CSK4, a toll-like receptor 2/6 agonist Pam2CSK4 Biotin Chemical Structure
  65. GC10273 Pam3CSK4

    Pam3Cys-Ser-(Lys)4

     Pam3CSK4 (Pam3CysSerLys4) is a synthetic triacylated lipopeptide (LP) and a TLR2/TLR1 ligand agonist with an EC50 of 0.47 ng/mL. Pam3CSK4 Chemical Structure
  66. GC16445 Pam3CSK4 Biotin

    Pam3Cys-Ser-(Lys)4-Biotin

     biotinylated Pam3CSK4, a toll-like receptor 1/2 agonist Pam3CSK4 Biotin Chemical Structure
  67. GC64486 Pepinh-TRIF TFA Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction. Pepinh-TRIF TFA Chemical Structure
  68. GC31792 PF-4878691 (3M-852A)

    3M-852A

     PF-4878691 (3M-852A) (3M-852A) is a potent, orally active, and selective Toll-like receptor 7 (TLR7) agonist modelled to dissociate its antiviral and inflammatory activities. PF-4878691 (3M-852A) Chemical Structure
  69. GC14710 Poly(I:C)

    Polyinosinic-polycytidylic acid

    Poly (I:C), a synthetic double-stranded RNA (dsRNA) analog, is an immunostimulant that acts as the most potent interferon (IFN) inducer.

     Poly(I:C) Chemical Structure
  70. GN10312 Polygalasaponin F Polygalasaponin F Chemical Structure
  71. GC13800 Polyinosinic-polycytidylic Acid (potassium salt)

    Poly(I:C)

     synthetic dsRNA that activates TLR3 and retinoic acid inducible gene 1 (RIG-1)-like receptors Polyinosinic-polycytidylic Acid (potassium salt) Chemical Structure
  72. GC60297 Polyinosinic-polycytidylic acid sodium Polyinosinic-polycytidylic acid sodium(Poly I:C) is a synthetic dsRNA that can imitate a viral infection and elicit host immune responses by triggering specific pattern-recognition receptors (PRRs) such as toll-like receptor 3(TLR3) and retinoic acid inducible gene I(RIG-I)-like receptors, including RIG-I and melanoma differentiation-associated gene. Polyinosinic-polycytidylic acid sodium Chemical Structure
  73. GN10348 Proanthocyanidin B1

    (-)-Epicatechin-(4β-8)-(+)-catechin, Proanthocyanidin B1, Procyanidol B1

     Proanthocyanidin B1 Chemical Structure
  74. GC13650 Resiquimod (R-848)

    Resiquimod, S 28463

     Resiquimod (R848) is an imidazoquinoline compound with potential antiviral activity. Resiquimod (R-848) Chemical Structure
  75. GC62636 Resiquimod-d5

    R848-d5; S28463-d5

     Resiquimod-d5 (R848-d5) is deuterium labeled Resiquimod. Resiquimod-d5 Chemical Structure
  76. GC60328 Robinin Robinin is present in?flavonoid?fraction of?Vigna unguiculata?leaf. Robinin Chemical Structure
  77. GC50297 RS 09 TLR4 peptide agonist; acts as an adjuvant in vivo RS 09 Chemical Structure
  78. GC63760 RS 09 TFA RS 09 TFA is a TLR4 agonist. RS 09 TFA Chemical Structure
  79. GC16538 RWJ 21757

    7-Allyl-8-Oxoguanosine, RWJ 21757

     RWJ 21757 (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. RWJ 21757 Chemical Structure
  80. GN10091 Schaftoside

    Apigenin 6-C-glucoside-8-C-arabinoside

     Schaftoside Chemical Structure
  81. GC50165 SM 324405 Potent TLR7 agonist SM 324405 Chemical Structure
  82. GC60344 Sparstolonin B Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B Chemical Structure
  83. GC64456 Stepharine Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine Chemical Structure
  84. GC61803 Sulfo-ara-F-NMN

    CZ-48

     Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN Chemical Structure
  85. GC14438 Suprofen

    NSC 303611, R 25061, (±)-Suprofen, TN 762

     dual COX-1/COX-2 inhibitor Suprofen Chemical Structure
  86. GC16148 TAK-242

    Resatorvid

     TAK 242 is a toll-like receptor 4 (TLR4) signaling inhibitor. TAK-242 Chemical Structure
  87. GC11294 TAK-242 S enantiomer

    Resatorvid (S enantiomer);TAK242 (S enantiomer);TAK 242 (S enantiomer)

    TLR 4 signaling inhibitor

     TAK-242 S enantiomer Chemical Structure
  88. GC33076 Telratolimod (MEDI 9197)

    MEDI9197, 3M-052

     Telratolimod (MEDI 9197) (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity. Telratolimod (MEDI 9197) Chemical Structure
  89. GC50374 TH 1020 Toll-like receptor (TLR) 5/Flagellin complex antagonist TH 1020 Chemical Structure
  90. GC64901 TLR7 agonist 4 TLR7 agonist 4 (Compound 1.2) is a TLR7 agonist with an EC50 of 4.3 nM. TLR7 agonist 4 Chemical Structure
  91. GC19357 TLR7-agonist-1 TLR7-agonist-1 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM. TLR7-agonist-1 Chemical Structure
  92. GC30516 TLR7/8 agonist 1 dihydrochloride A dual agonist of TLR7 and TLR8 TLR7/8 agonist 1 dihydrochloride Chemical Structure
  93. GC62395 TLR7/8 agonist 3 TLR7/8 agonist 3 is a potent TLR7 and TLR8 agonist, extracted from patent WO2016057618 (compound of formula (II)). TLR7/8 agonist 3 Chemical Structure
  94. GC65915 TLR7/8 agonist 4 TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist. TLR7/8 agonist 4 has anti-cancer activity. TLR7/8 agonist 4 Chemical Structure
  95. GC62668 TLR7/8-IN-1 TLR7/8-IN-1 is a crystalline from of a TLR7/TLR8 inhibitor extracted from patent WO2019220390, compound 2b. TLR7/8-IN-1 Chemical Structure
  96. GC67699 TLR8 agonist 5 TLR8 agonist 5 Chemical Structure
  97. GC17996 Toll-like receptor modulator Toll-like receptor modulator Chemical Structure
  98. GC64262 Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH Chemical Structure

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