GLPBio

Cyclin-Dependent Kinases

Cyclin-dependent kinases is a group of serine/threonine kinases. It is activated by binding to cyclin and participates in the regulation of cell cycle.

Products Related to Cyclin-Dependent Kinases(70)

  • GC10840 structure
    GC10840THZ1
    CAS: 1604810-83-4
    Purity: >98.50%

    Covalent CDK7 inhibitor,potent and selective

  • GC10842 structure
    GC10842LEE011
    CAS: 1211441-98-3
    Purity: >99.50%

    LEE011 is an ATP-competitive and orally active CDK4/6 inhibitor with IC50 values of 10nM and 39nM.

  • GC12438 structure
    GC12438AZD-5438
    CAS: 602306-29-6
    Purity: >99.50%

    Potent CDK1/2/9 inhibitor

  • GC17648 structure
    GC17648Dinaciclib(SCH727965)
    CAS: 779353-01-4
    Purity: >98.00%

    Dinaciclib(SCH727965) (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively.

  • GC11396 structure
    GC11396SNS-032 (BMS-387032)
    CAS: 345627-80-7
    Purity: >99.00%

    SNS-032 (BMS-387032) (BMS-387032) is a potent and selective inhibitor ofCDK2, CDK7, and CDK9 withIC50sof 38 nM, 62 nM and 4 nM, respectively. SNS-032 (BMS-387032) has antitumor effect.

  • GC11401 structure
    GC11401Roscovitine (Seliciclib,CYC202)
    CAS: 186692-46-6
    Purity: >98.00%

    Roscovitine (Seliciclib,CYC202) is an effective inhibitor of Cdk2/cyclin E with an IC 50 value of 0.1μM. Roscovitine also inhibits Cdk7/cyclin H, Cdk5/p35, and (cdc)/cyclin B, with IC 50 values of 0.49, 0.16, and 0.65μM, respectively.

  • GC11410 structure
    GC11410Aminopurvalanol A
    CAS: 220792-57-4
    Purity: >98%

    cyclin-dependent kinase inhibitor

  • GC11564 structure
    GC11564Cdk4/6 Inhibitor IV
    CAS: 359886-84-3
    Purity: >99.50%

    GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer.

  • GC11634 structure
    GC11634NSC 693868
    CAS: 40254-90-8
    Purity: >98%

    CDKs and GSK-3 inhibitor

  • GC11785 structure
    GC11785CDK4 inhibitor
    CAS: 1256963-02-6
    Purity: >98%

    CDK4/Cyclin D1 inhibitor

  • GC11823 structure
    GC11823LY2835219 free base
    CAS: 1231929-97-7
    Purity: >99.00%

    LY2835219 free base is a potent and selective inhibitor of CDK4 and CDK6 with IC 50 of 2nM and 10nM in cell-free assays, respectively.

  • GC11835 structure
    GC11835Deferasirox
    CAS: 201530-41-8
    Purity: >99.50%

    Deferasirox is an orally active iron chelator used to treat iron overload diseases.

  • GC11944 structure
    GC11944PF 4800567 hydrochloride
    CAS: 1391052-28-0
    Purity: >98%

    casein kinase 1ε inhibitor

  • GC11971 structure
    GC11971LY2857785
    CAS: 1619903-54-6
    Purity: >98.50%

    CDK9 inhibitor

  • GC12001 structure
    GC12001BS-181
    CAS: 1092443-52-1
    Purity: >98%

    A selective Cdk7 inhibitor

  • GC12064 structure
    GC12064SB1317
    CAS: 937270-47-8
    Purity: >99.50%

    A multi-kinase inhibitor

  • GC12348 structure
    GC12348Ro 3306
    CAS: 872573-93-8
    Purity: >98.00%

    Ro 3306 functions as the ATP-competitive inhibitor targeting CDK1/cyclin B1 with K i value of 35nmol/L, and targeting CDK1/cyclin A complexes with K i value of 110nmol/L.

  • GC12425 structure
    GC12425CDK inhibitor II
    CAS: 1269815-17-9
    Purity: >98.50%
  • GC12826 structure
    GC12826AZD-5597
    CAS: 924641-59-8
    Purity: >98%

    Potent CDK inhibitor

  • GC12865 structure
    GC12865BMS265246
    CAS: 582315-72-8
    Purity: >99.00%

    CDK1/2 inhibitor,potent and selective

  • GC12871 structure
    GC12871CDK9 inhibitor
    CAS: 1415559-43-1
    Purity: >98.50%
  • GC12886 structure
    GC12886NSC 625987
    CAS: 141992-47-4
    Purity: >98%

    Cyclin-dependent kinase (cdk) 4 inhibitor

  • GC13100 structure
    GC13100[Ala92]-p16 (84-103)
    CAS: 189064-08-2
    Purity: >98%

    inhibitor of cyclin-dependent kinase-4 (cdk4)/cyclin D1

  • GC13511 structure
    GC13511THZ2
    CAS: 1604810-84-5
    Purity: >99.50%

    CDK7 inhibitor