GLPBio

DCPIB

Catalog No.: GC14073Purity:>99.50%
COASDSData Sheet
volume-sensitive anion channel (VSAC) and and ICl,swell blocker

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DCPIB
Cas No.: 82749-70-0
10mM (in 1mL DMSO)In Stock
$103.00
1
1mgIn Stock
$40.00
1
5mgIn Stock
$93.00
1
10mgIn Stock
$137.00
1
25mgIn Stock
$230.00
1
50mgIn Stock
$344.00
1
100mgIn Stock
$504.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), voltage-dependently activates potassium channels TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3 (IC50s, 0.14, 0.95, 50.72 μM, respectively)[1]. DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM in CPAE cells[2].

References:
[1]. Lv J, et al. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci. 2019 Apr 17.
[2]. Decher N, et al. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol. 2001 Dec;134(7):1467-79.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
82749-70-0
Chemical Name
(R)-4-((2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid
SMILES
ClC1=C2C([C@@](CC2=CC(OCCCC(O)=O)=C1Cl)(CCCC)C3CCCC3)=O
Molecular Formula
C22H28Cl2O4
Molecular Weight
427.37
Solubility
<42.74mg/ml in ethanol
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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