GLPBio

Chloride Channel

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Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.

Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells.

Products Related to Chloride Channel(29)

  • GC11069 structure
    GC11069Meticrane
    CAS: 1084-65-7
    Purity: >98.00%

    Peripheral-type benzodiazepine receptor (PBR) inhibitor

  • GC13466 structure
    GC13466Flufenamic acid
    CAS: 530-78-9
    Purity: >99.50%

    TRPC activator

  • GC14073 structure
    GC14073DCPIB
    CAS: 82749-70-0
    Purity: >99.50%

    volume-sensitive anion channel (VSAC) and and ICl,swell blocker

  • GC14268 structure
    GC14268NPPB
    CAS: 107254-86-4
    Purity: >98.00%

    NPPB is a potent inhibitor of chloride channel with an IC 50 of 80nM for the short circuit current.

  • GC14768 structure
    GC14768CaCCinh-A01
    CAS: 407587-33-1
    Purity: >99.50%

    CaCCinh-A01 is an inhibitor of calcium-activated chloride channel (CaCC) TMEM16A, with an IC 50 value of 7.35 ± 0.86μM for TMEM16A current.

  • GC15308 structure
    GC15308IAA-94
    CAS: 54197-31-8
    Purity: >98.00%

    IAA-94 (Indanyloxyacetic acid-94) is an intracellular chloride channel blocker.

  • GC16564 structure
    GC16564Niflumic acid
    CAS: 4394-00-7
    Purity: >99.50%

    Ca2+-activated Cl- channel blocker

  • GC16890 structure
    GC16890Lubiprostone
    CAS: 136790-76-6
    Purity: >98.00%

    activator of ClC-2 chloride channels

  • GC17930 structure
    GC17930T16Ainh - A01
    CAS: 552309-42-9
    Purity: >98.50%

    T16Ainh - A01 is a potent transmembrane protein 16A (TMEM16A) inhibitor with an IC 50 value of 1μM for inhibiting TMEM16A chloride current.

  • GC18142 structure
    GC18142Eact
    CAS: 461000-66-8
    Purity: >98.00%

    Eact is a highly specific and potent activator of TMEM16A, which activates TMEM16A when the calcium ion concentration increases.

  • GC18358 structure
    GC18358MONNA
    CAS: 1572936-83-4
    Purity: >98%

    MONNA is a specific blocker of ANO1 (anoctamin-1/TMEM16A) calcium-activated chloride channels, with an IC 50 of 0.08μM for xANO1 in Xenopus laevis oocytes.

  • GC19021 structure
    GC19021Adjudin
    CAS: 252025-52-8
    Purity: >98.00%

    Adjudin is an extensively studied male contraceptive with a superior mitochondria-inhibitory effect.

  • GC30555 structure
    GC30555H100
    CAS: 643727-55-3
    Purity: >98%

    H100 is a Cl- transport inhibitor, with partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger, but no effect against KCl cotransporter, in human erythrocytes.

  • GC31133 structure
    GC31133NS1652
    CAS: 1566-81-0
    Purity: >99.50%

    NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells.

  • GC33024 structure
    GC33024Chlorotoxin
    CAS: 163515-35-3
    Purity: >98.00%

    Chlorotoxin is a polypeptide toxin isolated from the venom of the Israeli deathstalker scorpion.

  • GC34574 structure
    GC34574Endovion (Emidurdar)
    CAS: 265646-85-3
    Purity: >99.00%

    Endovion is an orally active anion channel inhibitor.

  • GC38498 structure
    GC38498Chlorotoxin (TFA)
    Purity: >98%
  • GC46086 structure
    GC46086Ani 9
    CAS: 356102-14-2
    Purity: >98.00%

    Ani 9 is a highly selective inhibitor of ANO1 that potently blocks ANO1 channel activity with an IC₅₀ below 3μM.

  • GC60834 structure
    GC60834Fenamic acid
    CAS: 91-40-7
    Purity: >98.00%

    Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker.

  • GC61186 structure
    GC61186Picrotoxinin
    CAS: 17617-45-7
    Purity: >98.00%

    Picrotoxinin is a bitter toxin derived from natural plants; it is found in the seeds of a climbing plant known as Anamirta cocculus and acts as a chloride channel blocker. Picrotoxinin is a non-competitive antagonist of the GABA A receptor, negatively modulating the effects of the neurotransmitter gamma-aminobutyric acid (GABA) on GABA A receptors.

  • GC63514 structure
    GC63514Irisolidone
    CAS: 2345-17-7
    Purity: >99.50%

    Irisolidone is a major isoflavone found in Pueraria lobata flowers.

  • GC65406 structure
    GC65406T16A(inh)-C01
    CAS: 171506-87-9
    Purity: >98%

    T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1).

  • GC68663 structure
    GC68663ANO1-IN-1
    CAS: 407587-01-3
    Purity: >98.00%

    ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with IC50 values of 2.56 μM and 15.43 μM for ANO1 and ANO2, respectively. ANO1-IN-1 strongly inhibits the proliferation of glioma cells.

  • GC70963 structure
    GC70963DFBTA
    CAS: 2966044-07-3
    Purity: >98.00%

    DFBTA is an orally active, potent and little brain penetrated ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC50 of 24 nM.