CPTH2 |
| Katalog-Nr.GC39365 |
CPTH2 ist ein potenter Hemmer der Histonacetyltransferase (HAT). CPTH2 hemmt selektiv die Acetylierung von Histon H3 durch Gcn5. CPTH2 induziert Apoptose und verringert die InvasivitÄt einer Zelllinie des klarzelligen Nierenkarzinoms (ccRCC) durch die Hemmung der Acetyltransferase p300 (KAT3B).
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Cas No.: 357649-93-5
Sample solution is provided at 25 µL, 10mM.
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CPTH2 is a potent histone acetyltransferase (HAT) inhibitor and selectively inhibits the acetylation of histone H3 by recombinant human Gcn5 in a substrate-competive manner. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2].
[1]. Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44. [2]. Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6.
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