DSPE-PEG2000-cRGD

DSPE-PEG2000-cRGD is a PEG compound which composed of DSPE and an αvβ3 targeting peptide (cRGD). cRGD peptide can specifically bind to αvβ3 on the surface of many cancer cells and neovascular cells. DSPE-PEG2000-cRGD can be used for drug delivery ^[1].

In Vitro, DSPE-PEG2000-cRGD can be used to construct pp-siRNA/CLD/DNCA/DSPE-PEG2000-cRGD (PCNR). pp-siRNA/CLD/DNCA/DSPE-PEG2000-cRGD nanoparticles can specifically target tumor cells that highly express integrin αvβ3^[2]. Incorporating DSPE-PEG2000-cRGD into liposomes can form spatially stable and integrin-targeting liposomes^[3]. DSPE-PEG2000-cRGD can be used to construct C-siRNA/MTSLR-U and C-siRNA/MTSLR, which have anti-hepatocellular carcinoma activity^[4].

References:
[1]. Gajbhiye KR, et al. cRGD functionalised nanocarriers for targeted delivery of bioactives. J Drug Target. 2019 Feb;27(2):111-124.
[2]. Zhang Y, et al. Construction of a Targeting Nanoparticle of 3',3″-Bis-Peptide-siRNA Conjugate/Mixed Lipid with Postinserted DSPE-PEG2000-cRGD. Mol Pharm. 2019 Dec 2;16(12):4920-4928.
[3]. Khabazian E, et al. Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells. J Drug Target. 2022 Jun;30(5):522-533.
[4]. Nai J, et al. Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells. Mol Ther Nucleic Acids. 2021 Dec 11;27:349-362.