Fucosterol (Synonyms: 24-ethylidene Cholesterol) |
Katalog-Nr.GC10456
One-Click Copy Product Info
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Fucosterol ist ein Sterin, das aus Algen, Algen oder Diatomeen isoliert wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 17605-67-3
Sample solution is provided at 25 µL, 10mM.
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Fucosterol is a plant sterol found in algae that has diverse biological activities including antioxidant, anti-inflammatory, anticancer, and antidiabetic properties among others.[1] It decreases markers of oxidative damage and increases antioxidative enzyme activity in vitro.[2] It reduces the expression of TNF-α and IL-6 following LPS administration by halting NF-κB and p38 MAPK signaling in RAW 264.7 murine macrophages.[3] In HEK293, MCF-7, and SiHa cells, fucosterol decreases proliferation (IC50s = 185.4, 43.3, and 34.0 µg/ml, respectively).[4] It also has anticancer activity in HL-60 leukemia cells, where it inhibits cell growth, halts the cell cycle at the G2/M transition, and induces apoptosis with maximally increased caspase-9, -8, and -3 expression at 68.8 µM.[5] In a streptozotocin rat model of diabetes, it decreases serum glucose concentrations when administered at 30 mg/kg.[6]
Reference:
[1]. Abdul, Q.A., Choi, R.J., Jung, H.A., et al. Health benefit of fucosterol from marine algae: A review J. Sci. Food Agric. 96(6), 1856-1866 (2015).
[2]. Lee, S., Lee, Y.S., Jung, S.H., et al. Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa Arch. Pharm. Res. 26(9), 719-722 (2003).
[3]. Yoo, M.S., Shin, J.S., Choi, H.E., et al. Fucosterol isolated from Undaria pinnatifida inhibits lipopolysaccharide-induced production of nitric oxide and pro-inflammatory cytokines via the inactivation of nuclear factor-κB and p38 mitogen-activated protein kinase in RAW264.7 macrophages Food Chem. 135(3), 967-975 (2012).
[4]. Caamal-Fuentes, E., Moo-Puc, R., Freile-Pelegrin, Y., et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata Pharm. Biol. 52(10), 1244-1248 (2014).
[5]. Yi, Y.B., Ji, C.F., and Yue, L. Study on human promyelocytic leukemia HL-60 cells apoptosis induced by fucosterol Biomed. Mater. Eng. 24(1), 845-851 (2014).
[6]. Lee, Y.S., Shin, K.H., Kim, B.K., et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa Arch. Pharm. Res. 27(11), 1120-1122 (2004).
| Cas No. | 17605-67-3 | SDF | |
| Überlieferungen | 24-ethylidene Cholesterol | ||
| Chemical Name | (3β,24E)-stigmasta-5,24(28)-dien-3-ol | ||
| Canonical SMILES | C/C=C(C(C)C)\CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C | ||
| Formula | C29H48O | M.Wt | 412.7 |
| Löslichkeit | 24-ethylidene Cholesterol | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.4231 mL | 12.1153 mL | 24.2307 mL |
| 5 mM | 484.6 μL | 2.4231 mL | 4.8461 mL |
| 10 mM | 242.3 μL | 1.2115 mL | 2.4231 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)