Fuscin |
| Katalog-Nr.GC40008 |
Fuscin, ein Pilzmetabolit, CCR5-Rezeptorantagonist mit Anti-HIV-Wirkung.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 83-85-2
Sample solution is provided at 25 µL, 10mM.
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Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner. It competes with macrophage inflammatory protein 1α (MIP-1α) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 μM.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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