Startseite>>Infectious Disease>> Bacterial Diseases>> Food-Borne Illnesses>>Chartreusin

Chartreusin (Synonyms: Antibiotic X 465A, Lambdamycin, NSC 5159)

Katalog-Nr.GC18536 Copy One-Click Copy Product Info

Chartreusin is an antibiotic originally isolated from S.

Products are for research use only. Not for human use. We do not sell to patients.

Chartreusin Chemische Struktur

Cas No.: 6377-18-0

Größe Preis Lagerbestand Menge
1mg
76,00 $
Auf Lager
5mg
220,00 $
Auf Lager

Tel:(909) 407-4943 Email: sales@glpbio.com


Kundenbewertungen

Basiert auf Kundenrezensionen.

Sample solution is provided at 25 µL, 10mM.



Description of Chartreusin

Chartreusin is an antibiotic originally isolated from S. chartreusis with diverse biological activities. It inhibits growth of S. aureus, B. subtilis, M. luteus, M. flavus, B. fragilis, C. difficile, C. perfringens, and P. acnes (MICs = 0.4-12.5 μg/ml). Chartreusin binds to DNA and induces electrophoretic shifts in both supercoiled and nicked plasmid DNA. It also inhibits strand-passing activity of topoisomerase II in a P4 unknotting assay. Chartreusin inhibits protein synthesis in chick embryo fibroblasts (CEFs) and mouse fibroblast 3T6 cells (IC50s = 7 and 70 μM, respectively). It is cytotoxic to human lung carcinoma A549 cells in vitro (IC50 = 95 nM) and increases median survival in P388 leukemia and B16 melanoma mouse tumor models when administered at a dose of 10 mg/kg per day.

Chemical Properties of Chartreusin

Cas No. 6377-18-0 SDF
Überlieferungen Antibiotic X 465A, Lambdamycin, NSC 5159
Chemical Name 10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione
Canonical SMILES OC1=C(C(OC2=C3C(C(O4)=O)=C(C)C=C2)=O)C3=C4C5=C1C=CC=C5O[C@@H]6O[C@H](C)[C@H](O)[C@H](O)[C@H]6O[C@]7([H])[C@H](O)[C@@H](OC)[C@@H](O)[C@@H](C)O7
Formula C32H32O14 M.Wt 640.6
Löslichkeit Acetone: soluble,DMSO: 10 mg/ml,Methanol: slightly soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Chartreusin

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.561 mL 7.8052 mL 15.6104 mL
5 mM 312.2 μL 1.561 mL 3.1221 mL
10 mM 156.1 μL 780.5 μL 1.561 mL
  • Molaritätsrechner

  • Verdünnung-Rechner

  • Molecular Weight Calculator

Gewicht
=
Konzentration
x
Inhalt
x
MW*
 
 
 
**Bei der Herstellung von Stammlösungen ist immer das chargenspezifische Molekulargewicht von

Berechnen

In vivo Formulation Calculator (Clear solution) of Chartreusin

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

View current batch:

Bewertungen

Review for Chartreusin

Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%