PF-03654746 |
| Katalog-Nr.GC36878 |
PF-03654746 ist ein potenter und selektiver Histamin-H3-Rezeptorantagonist mit hoher Hirndurchdringung.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 935840-31-6
Sample solution is provided at 25 µL, 10mM.
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PF-03654746 is a potent and selective histamine H3 receptor antagonist with high brain penetration.PF-03654746 reduces allergen-induced nasal symptoms, might be a novel therapeutic strategy to further explore allergic rhinitis[1].PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].
[1]. Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. [2]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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