GSK-843 (Synonyms: GSK'843) |
| Katalog-Nr.GC34606 |
GSK-843 (GSK'843) ist ein Inhibitor der Rezeptor-interagierenden Proteinkinase 3 (RIP3 oder RIPK3), der die RIP3-KinasedomÄne mit einem IC50 von 8,6 nM bindet und die KinaseaktivitÄt mit einem IC50 von 6,5 nM hemmt.
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Cas No.: 1601496-05-2
Sample solution is provided at 25 µL, 10mM.
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GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1]. IC50: 6.5 nM (RIP3)[1]
[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.
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