HIF-1α-IN-2 |
| Katalog-Nr.GC66464 |
HIF-1α-IN-2 ist ein wirksames HIF-1&7#945; Inhibitor mit Antikrebspotenzen (IC50s von 28 nM und 15 nM in MDA-MB-231- bzw. MiaPaCa-2-Zellen). HIF-1α-IN-2 unterdrÜckt HIF-1α Expression durch Blockieren der Transkription und Proteintranslation.
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Cas No.: 2762315-06-8
Sample solution is provided at 25 µL, 10mM.
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HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation[1].
HIF-1α-IN-2 (compound 7f) (5 μM; 72h) suppresses the viability of MDA-MB-231 and MiaPaCa-2 cells with IC50s of 28 nM and 15 nM, respectively[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses the expression of HIF-1α and VEGF with dose-dependent effect[1].
HIF-1α-IN-2 (0.25, 0.5, and 1 µM; 16-24h) can significantly inhibit the migration of MDA-MD-231 cells by 56% (0.25 µM), 83% (0.5 µM), and 85% (1 µM), respectively, and also noted in MiaPaCa-2 cells, which demonstrates the unique anti-migration effect of HIF-1α-IN-2[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses HIF-1α mRNA levels in MDA-MB-231 cells under hypoxia[1].
Cell Viability Assay
| Cell Line: | MDA-MB-231 cells, MiaPaCa-2 cells[1] |
| Concentration: | 5 μM |
| Incubation Time: | 72 hours |
| Result: | Suppressed the viability of these two cell lines with IC50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively. |
Cell Viability Assay
| Cell Line: | MDA-MB-231 cells, MiaPaCa-2 cells[1] |
| Concentration: | 5 μM |
| Incubation Time: | 72 hours |
| Result: | Suppressed the viability of these two cell lines with IC50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively. |
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