KIN101 |
Katalog-Nr.GC64253
One-Click Copy Product Info
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KIN101 ist ein potenter viraler RNA-Inhibitor mit IC50-Werten von 2 μM, >5 μM fÜr Influenzavirus bzw. Dengue-Virus (DNV).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 610753-87-2
Sample solution is provided at 25 µL, 10mM.
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KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses[1][2].
KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1].KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels[1].KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1].KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1].KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV)[2].
[1]. Bedard KM, et al. Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses. J Virol. 2012 Jul;86(13):7334-44.
[2]. Shawn P. Iadonato, et al. Anti-viral compounds, pharmaceutical compositions and methods of use thereof. US20160122312A1.
| Cas No. | 610753-87-2 | SDF | |
| Formula | C16H11BrO5S | M.Wt | 395.22 |
| Löslichkeit | DMSO : 41.67 mg/mL (105.43 mM; ultrasonic and warming and heat to 60°C) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5302 mL | 12.6512 mL | 25.3024 mL |
| 5 mM | 506 μL | 2.5302 mL | 5.0605 mL |
| 10 mM | 253 μL | 1.2651 mL | 2.5302 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)