KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability.
References:
[1]. Wang Y, et al. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129505. doi:10.1016/j.bmcl.2023.129505