GLPBio

Monensin sodium salt

Catalog No.: GC16995Purity:>98.00%Synonyms: Monensin A, NSC 343257
COASDSData Sheet
Monensin-Natriumsalz ist ein Antibiotikum, das von den Bakterien Streptomyces cinnamonensis abgesondert wird.

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Monensin sodium salt
Cas No.: 22373-78-0
10 mM * 1 mL in EthanolIn Stock
$31.00
1
100mgIn Stock
$28.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Beschreibung (Description)

Monensin sodium salt is a polyether ionophore antibiotic that exhibits antibacterial activity against a variety of Gram-positive bacteria. Monensin sodium salt is used for the treatment and prevention of coccidiosis in poultry and other livestock [1]. Monensin sodium salt is an ionophore that mediates Na+/H+ exchange and is used as a tool to study ionophore mechanisms[2]. Additionally, Monensin sodium salt is an effective inhibitor of Wnt signaling[3]. Monensin sodium salt also has the potential to inhibit cancer development[4].

In vitro, treatment of human colorectal cancer cells RKO and HCT-116 with Monensin sodium salt (4μM) significantly inhibits cell proliferation, migration, and cell cycle progression, while inducing apoptosis and G1 arrest. Moreover, Monensin sodium salt can suppress the expression of IGF1R by increasing the expression of IGF1[5]. Monensin sodium salt (0.1–10μM) treatment of human peripheral blood eosinophils for 2 hours induces apoptosis-like cell death, with minimal effects on neutrophils[6].

In vivo, Monensin sodium salt (1mg/kg) was administered intraperitoneally to BALB/c mice sensitized with house dust mite (HDM) for 6 weeks. Monensin sodium salt significantly reduced the infiltration of eosinophils and lymphocytes into the airway lumen and decreased the lung tissue inflammation score[7]. Monensin sodium salt (10mg/kg) was administered intraperitoneally in a xenograft tumor model established with the pancreatic cancer cell line Panc-1. Monensin sodium salt significantly inhibited tumor growth, reduced tumor volume, and decreased the expression of proliferating cell nuclear antigen (PCNA) and epidermal growth factor receptor (EGFR) in the tumor tissues[8].

References:
[1] Rajendran V, Ilamathi HS, Dutt S, et al. Chemotherapeutic Potential of Monensin as an Anti-microbial Agent. Curr Top Med Chem. 2018;18(22):1976-1986.
[2] Dias SADN, Divyasorubini S, Gamage KTJ, et al. Na+/K+ carrier ionophore antibiotics valinomycin and monensin enhance the antibacterial activity of fluoride. J Antibiot (Tokyo). 2023 Jul;76(7):425-429.
[3] Fu B, Fang L, Wang R, et al. Inhibition of Wnt/β-catenin signaling by monensin in cervical cancer. Korean J Physiol Pharmacol. 2024 Jan 1;28(1):21-30.
[4] Markowska A, Kaysiewicz J, Markowska J, et al. Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1549-1554.
[5] Zhou Y, Deng Y, Wang J, et al. Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells. Ann Med. 2023 Dec;55(1):954-964.
[6] Vraila M, Asp E, Melo FR, et al. Monensin induces secretory granule-mediated cell death in eosinophils. J Allergy Clin Immunol. 2023 Nov;152(5):1312-1320.e3.
[7] Allam VSRR, Akula S, Waern I, et al. Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice. Inflammation. 2025 Apr;48(2):806-819.
[8] Wang X, Wu X, Zhang Z, et al. Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway. Sci Rep. 2018 Dec 17;8(1):17914.

Protokoll (Protocol)

Cell experiment [1]:

Cell lines

Human colorectal cancer cell lines RKO and HCT-116

Preparation Method

RKO and HCT-116 cells were maintained in complete Dulbecco's Modified Eagle's Medium (DMEM) containing 10% fetal bovine serum (FBS), 100 units of penicillin, and 100μg of streptomycin at 37°C in a humidified atmosphere with 5% CO₂. Cells were treated with varied concentrations of Monensin sodium salt (0–8μM) for 24–48 hours.

Reaction Conditions

0–8μM; 24–48h.

Applications

Monensin sodium salt effectively inhibited cell proliferation and migration in a dose-dependent and time-dependent manner. Monensin sodium salt also induced apoptosis and G1 arrest in both cell lines. Monensin sodium salt targeted multiple cancer-related signaling pathways, including Elk1, AP1, and Myc/max, and suppressed IGF1R expression via increasing IGF1 in colorectal cancer cells.
Animal experiment [2]:

Animal models

Nude mice

Preparation Method

Firefly luciferase-tagged Panc-1 cells were subcutaneously injected into the flanks of athymic nude mice. After 3 days, the mice were randomly divided into two groups and treated with Monensin sodium salt (10mg/kg) or vehicle control. Tumor progression was monitored through whole body Xenogen bioluminescence imaging at 7, 11, 16, and 26 days post-treatment. Mice were sacrificed after 4 weeks.

Dosage form

10mg/kg; i.p.

Applications

Monensin effectively suppressed tumor growth, reduced tumor volume, and decreased the expression of the cell proliferation marker PCNA and EGFR in the tumor samples.

References:
[1] Zhou Y, Deng Y, Wang J, et al. Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells. Ann Med. 2023 Dec;55(1):954-964.
[2] Wang X, Wu X, Zhang Z, et al. Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway. Sci Rep. 2018 Dec 17;8(1):17914.

Produktdokumente (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemische Eigenschaften (Chemical Properties)

CAS-Nr.
22373-78-0
Synonyme
Monensin A, NSC 343257
SMILES
O[C@H]1C[C@]2(O[C@H]([C@H](C)[C@@H]([C@@H](C([O-])=O)C)OC)[C@@H]1C)O[C@@](CC2)(C)[C@@H]3O[C@](CC3)(CC)[C@H]4O[C@H]([C@H]([C@@H](C)C[C@H]5C)O[C@]5(CO)O)C[C@H]4C.[Na+]
Summenformel
C36H61NaO11
Molekulargewicht
692.85
Löslichkeit
≥ 69.3mg/mL in EtOH with ultrasonic, <6.93mg/mL in DMSO
Lagerung
Store at -20°C
Allgemeine Hinweise
Wählen Sie anhand der Löslichkeitsdaten des Produkts ein geeignetes Lösungsmittel. Aliquotieren Sie die Stammlösung nach der Herstellung, um wiederholte Gefrier-Auftau-Zyklen zu vermeiden.
Verwenden Sie Stammlösungen bei Lagerung bei -80°C innerhalb von 6 Monaten bzw. bei -20°C innerhalb von 1 Monat.
Zur Verbesserung der Löslichkeit das Röhrchen auf 37°C erwärmen und für eine angemessene Dauer beschallen.
Versandbedingungen
Evaluierungsmuster werden mit Kühlakkus versandt. Andere verfügbare Größen werden bei Raumtemperatur oder auf Anfrage mit Kühlakkus versandt.

Rechner (Calculators)Molarität / Verdünnung / Molekulargewicht / Einheitenumrechnung / In-vivo-Formulierung / Löslichkeit

g/mol

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