NSC 12 (Synonyms: NSC 172285) |
| Katalog-Nr.GC44465 |
NSC 12 ist eine extrazellulÄre Falle des Fibroblasten-Wachstumsfaktors 2 (FGF2), der FGF2 bindet und seine Wechselwirkung mit FGFR1 stÖrt. NSC 12 hemmt die Proliferation verschiedener FGF-abhÄngiger Tumorzellen sowohl in vitro als auch in vivo ohne systemische toxische Wirkungen.
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Cas No.: 102586-30-1
Sample solution is provided at 25 µL, 10mM.
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NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 µM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs). NSC 12 also binds several other, but not all, FGF isoforms with Kd values ranging between 16 and 120 µM, preventing them from forming HSPG/FGF/FGFR ternary complexes. NSC 12 inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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