Ppc-1 is a prenylated quinolinecarboxylic acid originally isolated from P. pseudo-candidum that has diverse biological activities.1,2,3 It reduces the proliferation of K562 chronic myelogenous leukemia (CML) cells and 3T3-L1 mouse fibroblasts when used at a concentration of 15 ?M.1 Ppc-1 (1 and 10 ?M) inhibits the production of IL-2 induced by concanavalin A in Jurkat T cells.2 In vivo, Ppc-1 (0.8 mg/kg) reduces body weight gain and increases serum fatty acid levels in mice fed a commercial diet.3
References:
[1]. Kikuchi, H., Nakamura, K., Kubohara, Y., et al.Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime moldsTetrahedron66(32)6000-6007(2010).
[2]. Ogura, M., Kikuchi, H., Suzuki, T., et al.Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2Biochem Pharmacol.10555-65(2016).
[3]. Suzuki, T., Kikuchi, H., Ogura, M., et al.Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime moldPLoS One10(2)e0117088(2015).